Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit

Cephalexin is a first generation cephalosporin widely used in rabbits. Its spectrum includes Pasteurella multocida and Staphylococcus aureus. These bacteria, together with Bordetella bronchiseptica, are the main cause of respiratory infections. Although many textbooks on rabbit therapeutics report t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Meneses, María Laura, Albarellos, Gabriela Alejandro, Landoni, María Fabiana
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2013
Materias:	Ciencias Veterinarias Cephalexin Rabbit Pharmacokinetics Multiple intramuscular administration.
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/99119 https://ri.conicet.gov.ar/11336/23692 http://ibimapublishing.com/articles/IJVMR/2013/898594/
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-99119
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Veterinarias Cephalexin Rabbit Pharmacokinetics Multiple intramuscular administration.
spellingShingle	Ciencias Veterinarias Cephalexin Rabbit Pharmacokinetics Multiple intramuscular administration. Meneses, María Laura Albarellos, Gabriela Alejandro Landoni, María Fabiana Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit
topic_facet	Ciencias Veterinarias Cephalexin Rabbit Pharmacokinetics Multiple intramuscular administration.
description	Cephalexin is a first generation cephalosporin widely used in rabbits. Its spectrum includes Pasteurella multocida and Staphylococcus aureus. These bacteria, together with Bordetella bronchiseptica, are the main cause of respiratory infections. Although many textbooks on rabbit therapeutics report the use of cephalexin, including administration schedules, there are not published papers on the pharmacokinetics of cephalexin after IV and IM administration to rabbit. Therefore, the objective of the present study was to describe cephalexin disposition in rabbits after intravenous and single and multiple intramuscular administrations. Three administration schedules were studied: single IV administration (10 mg/kg), single IM administration (10 mg/kg) and multiple IM administration (2.5 mg/kg/6). Serial blood samples were collected over a 24 h period. Cephalexin plasma concentrations were determined by microbiological method using Kocuria rhizophila ATCC 9341 as microorganism test. No statistical differences were observed between routes of administration for any of the estimated PK parameters. The unique difference was observed on bioavailability between intramuscular administration schedules. Elimination half-life was 1.45, 1.09 and 1.91 h for the single IV, single IM and multiple IM administration, respectively. Bioavailability after single and multiple IM administration was 47 and 97.5%, respectively. After multiple IM administration maximum and minimum plasma concentration at steady state were 2.77 and 0.34 µg/ml, while Cmax after single IM administration was 9. 22 µg/ml. Considering that for betalactams the PK/PD breakpoint recommended for efficacy (T > MIC) should be 50–80% and that the reported MIC for most gram-positive organisms and Pasteurella multocida is ≤1.0 μg/ml, the present study demonstrates that a single IM dose of 10 mg/kg/24 h is enough to maintain therapeutic concentrations for a 24 hours period. When a 2.5mg/kg dose is used administration every 6 hours is recommended.
format	Articulo Articulo
author	Meneses, María Laura Albarellos, Gabriela Alejandro Landoni, María Fabiana
author_facet	Meneses, María Laura Albarellos, Gabriela Alejandro Landoni, María Fabiana
author_sort	Meneses, María Laura
title	Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit
title_short	Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit
title_full	Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit
title_fullStr	Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit
title_full_unstemmed	Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit
title_sort	pharmacokinetics of cephalexin after intravenous and single and multiple intramuscular administration to rabbit
publishDate	2013
url	http://sedici.unlp.edu.ar/handle/10915/99119 https://ri.conicet.gov.ar/11336/23692 http://ibimapublishing.com/articles/IJVMR/2013/898594/
work_keys_str_mv	AT menesesmarialaura pharmacokineticsofcephalexinafterintravenousandsingleandmultipleintramuscularadministrationtorabbit AT albarellosgabrielaalejandro pharmacokineticsofcephalexinafterintravenousandsingleandmultipleintramuscularadministrationtorabbit AT landonimariafabiana pharmacokineticsofcephalexinafterintravenousandsingleandmultipleintramuscularadministrationtorabbit
bdutipo_str	Repositorios
_version_	1764820492919767041

Pharmacokinetics of Cephalexin after Intravenous and Single and Multiple Intramuscular Administration to Rabbit

Ejemplares similares