G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model

Dendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due to their derivatisable branched architecture and possibility to modify them in numerous ways. Here, G4.5 PAMAM dendrimers were obtained as carriers of the antipsychotic drug risperidone. Despite th...

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Autores principales:	Prieto, María Jimena, del Río Zabala, Nahuel Eduardo, Marotta, Cristian Hernán, Bichara, Darío Román, Simonetta, Sergio Hernán, Chiaramoni, Nadia Silvia, Alonso, Silvia del Valle
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2013
Materias:	Química G4.5 Pamam Locomotor Risp Zebrafish
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/98691 https://ri.conicet.gov.ar/11336/24512 https://www.omicsonline.org/open-access/g-pamam-dendrimerrisperidone-biodistribution-and-behavioral-changes-in-in-vivo-model-2155-983X.1000121.php?aid=23468 https://www.longdom.org/abstract/g45-pamam-dendrimerrisperidone-biodistribution-and-behavioral-changes-in-emin-vivoem-model-20854.html
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química G4.5 Pamam Locomotor Risp Zebrafish
spellingShingle	Química G4.5 Pamam Locomotor Risp Zebrafish Prieto, María Jimena del Río Zabala, Nahuel Eduardo Marotta, Cristian Hernán Bichara, Darío Román Simonetta, Sergio Hernán Chiaramoni, Nadia Silvia Alonso, Silvia del Valle G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
topic_facet	Química G4.5 Pamam Locomotor Risp Zebrafish
description	Dendritic polymers are considered as emerging and outstanding carriers as modern medicinal systems due to their derivatisable branched architecture and possibility to modify them in numerous ways. Here, G4.5 PAMAM dendrimers were obtained as carriers of the antipsychotic drug risperidone. Despite their extensive applicability in the pharmaceutical field, the use of dendrimers as carriers in biological systems is constrained due to their inherent associated toxicity. The biocompatibility of dendrimers and dendrimer-risperidone complexes was evaluated in vivo for biological performance. To this end, the pharmacokinetics and biodistribution after oral treatment of free risperidone and dendrimer-risperidone complexes were studied in healthy mice. Also, the behavioral changes such as locomotion, aggression, dominance in male and female mice were evaluated both after a single dose and after daily therapy for 8 days. Also, in vivo effects of risperidone and dendrimer-risperidone complexes on the locomotion of zebrafish larvae were explored. The data obtained suggest that the unmetabolized risperidone complexes increase the arrival to the brain after 90 minutes. On the other hand, behavioral studies showed an increase in the potency of the drug in animals treated with the complexes
format	Articulo Articulo
author	Prieto, María Jimena del Río Zabala, Nahuel Eduardo Marotta, Cristian Hernán Bichara, Darío Román Simonetta, Sergio Hernán Chiaramoni, Nadia Silvia Alonso, Silvia del Valle
author_facet	Prieto, María Jimena del Río Zabala, Nahuel Eduardo Marotta, Cristian Hernán Bichara, Darío Román Simonetta, Sergio Hernán Chiaramoni, Nadia Silvia Alonso, Silvia del Valle
author_sort	Prieto, María Jimena
title	G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title_short	G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title_full	G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title_fullStr	G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title_full_unstemmed	G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model
title_sort	g4.5 pamam dendrimer-risperidone: biodistribution and behavioral changes in in vivo model
publishDate	2013
url	http://sedici.unlp.edu.ar/handle/10915/98691 https://ri.conicet.gov.ar/11336/24512 https://www.omicsonline.org/open-access/g-pamam-dendrimerrisperidone-biodistribution-and-behavioral-changes-in-in-vivo-model-2155-983X.1000121.php?aid=23468 https://www.longdom.org/abstract/g45-pamam-dendrimerrisperidone-biodistribution-and-behavioral-changes-in-emin-vivoem-model-20854.html
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G4.5 Pamam Dendrimer-Risperidone: Biodistribution and Behavioral Changes in In Vivo Model

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