Deoxythymidine–Pterin Fluorescent Adduct Formation through a Photosensitized Process

A new fluorescent compound was isolated from UVA-irradiated aqueous solutions containing pterin (Ptr) and 2′deoxythymidine (dT) in anaerobic conditions. Pterins are widespread in living systems in small amounts, but they are accumulated in some pathological situations. Under UVA radiation, pterins a...

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Detalles Bibliográficos
Autores principales: Estébanez Ruiz, Sandra, Thomas, Andrés Héctor, Lorente, Carolina
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2017
Materias:
Química
2′-deoxythymidine
Electron transfer
Photosensitization
Pterins
Radicals
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/98671
https://ri.conicet.gov.ar/11336/63805
https://onlinelibrary.wiley.com/doi/abs/10.1002/cphc.201701101
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-98671
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
2′-deoxythymidine
Electron transfer
Photosensitization
Pterins
Radicals
spellingShingle Química
2′-deoxythymidine
Electron transfer
Photosensitization
Pterins
Radicals
Estébanez Ruiz, Sandra
Thomas, Andrés Héctor
Lorente, Carolina
Deoxythymidine–Pterin Fluorescent Adduct Formation through a Photosensitized Process
topic_facet Química
2′-deoxythymidine
Electron transfer
Photosensitization
Pterins
Radicals
description A new fluorescent compound was isolated from UVA-irradiated aqueous solutions containing pterin (Ptr) and 2′deoxythymidine (dT) in anaerobic conditions. Pterins are widespread in living systems in small amounts, but they are accumulated in some pathological situations. Under UVA radiation, pterins are photochemically active, fluorescent, and photosensitize the generation of singlet oxygen [1O2(1Δg)]. The isolated compound was structurally characterized by using liquid chromatography coupled to tandem mass spectrometry, and its photophysical properties were studied with the time-correlated single-photon-counting technique. The molecular weight and the analysis of the fragmentation correspond to a molecule where the pterinic moiety is attached to the thymine nucleobase. The product exhibits photophysical properties similar to those of Ptr, including relatively high fluorescence and 1O2 production quantum yields.
format Articulo
Preprint
author Estébanez Ruiz, Sandra
Thomas, Andrés Héctor
Lorente, Carolina
author_facet Estébanez Ruiz, Sandra
Thomas, Andrés Héctor
Lorente, Carolina
author_sort Estébanez Ruiz, Sandra
title Deoxythymidine–Pterin Fluorescent Adduct Formation through a Photosensitized Process
title_short Deoxythymidine–Pterin Fluorescent Adduct Formation through a Photosensitized Process
title_full Deoxythymidine–Pterin Fluorescent Adduct Formation through a Photosensitized Process
title_fullStr Deoxythymidine–Pterin Fluorescent Adduct Formation through a Photosensitized Process
title_full_unstemmed Deoxythymidine–Pterin Fluorescent Adduct Formation through a Photosensitized Process
title_sort deoxythymidine–pterin fluorescent adduct formation through a photosensitized process
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/98671
https://ri.conicet.gov.ar/11336/63805
https://onlinelibrary.wiley.com/doi/abs/10.1002/cphc.201701101
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AT thomasandreshector deoxythymidinepterinfluorescentadductformationthroughaphotosensitizedprocess
AT lorentecarolina deoxythymidinepterinfluorescentadductformationthroughaphotosensitizedprocess
bdutipo_str Repositorios
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