Effect of Different Terpene-Containing Essential Oils on the Proliferation of <i>Echinococcus granulosus</i> Larval Cells
Human cystic echinococcosis remains a major public health problem on several countries and the treatment strategies are not solved. The aim of the present work was to determine the in vitro effect of thymol and Mentha piperita, M. pulegium, and Rosmarinus officinalis essential oils on the proliferat...
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/98361 https://ri.conicet.gov.ar/11336/34859 https://www.hindawi.com/journals/ipid/2014/746931/ |
| Aporte de: |
| id |
I19-R120-10915-98361 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Veterinarias Echinococcus granulosus Larval cells Essential oils Mentha piperita Mentha pulegium Rosmarinus officinalis Thymol |
| spellingShingle |
Ciencias Veterinarias Echinococcus granulosus Larval cells Essential oils Mentha piperita Mentha pulegium Rosmarinus officinalis Thymol Albani, Clara Maria Denegri, Guillermo María Elissondo, María Celina Effect of Different Terpene-Containing Essential Oils on the Proliferation of <i>Echinococcus granulosus</i> Larval Cells |
| topic_facet |
Ciencias Veterinarias Echinococcus granulosus Larval cells Essential oils Mentha piperita Mentha pulegium Rosmarinus officinalis Thymol |
| description |
Human cystic echinococcosis remains a major public health problem on several countries and the treatment strategies are not solved. The aim of the present work was to determine the in vitro effect of thymol and Mentha piperita, M. pulegium, and Rosmarinus officinalis essential oils on the proliferation of E. granulosus larval cells. Isolated cells and cellular aggregates were obtained from hydatid cyst's germinal layer and exposed to 1, 5, and 10 μg/ml of thymol and the different essential oils for 7 days. Drug effect was evaluated using test viability and scanning electron microscopy. Control cell culture viability was 2.1 x 10(6) (100%) after 7 days of incubation. At day 7, thymol 5 μg/ml caused a reduction in cell viability of 63% and the essential oils of M. piperita 10 μg/ml, M. pulegium 10 μg/ml, and R. officinalis 10 μg/ml produced a reduction in the viability of 77, 82, and 71%, respectively. Moreover essential oils caused reduction in cell number, collapsed cells, and loss of normal tridimensional composition of the aggregates. Due to the inhibitory effect caused by essential oils on E. granulosus cells we suggested that it would be an effective means for suppression of larval growth. |
| format |
Articulo Articulo |
| author |
Albani, Clara Maria Denegri, Guillermo María Elissondo, María Celina |
| author_facet |
Albani, Clara Maria Denegri, Guillermo María Elissondo, María Celina |
| author_sort |
Albani, Clara Maria |
| title |
Effect of Different Terpene-Containing Essential Oils on the Proliferation of <i>Echinococcus granulosus</i> Larval Cells |
| title_short |
Effect of Different Terpene-Containing Essential Oils on the Proliferation of <i>Echinococcus granulosus</i> Larval Cells |
| title_full |
Effect of Different Terpene-Containing Essential Oils on the Proliferation of <i>Echinococcus granulosus</i> Larval Cells |
| title_fullStr |
Effect of Different Terpene-Containing Essential Oils on the Proliferation of <i>Echinococcus granulosus</i> Larval Cells |
| title_full_unstemmed |
Effect of Different Terpene-Containing Essential Oils on the Proliferation of <i>Echinococcus granulosus</i> Larval Cells |
| title_sort |
effect of different terpene-containing essential oils on the proliferation of <i>echinococcus granulosus</i> larval cells |
| publishDate |
2014 |
| url |
http://sedici.unlp.edu.ar/handle/10915/98361 https://ri.conicet.gov.ar/11336/34859 https://www.hindawi.com/journals/ipid/2014/746931/ |
| work_keys_str_mv |
AT albaniclaramaria effectofdifferentterpenecontainingessentialoilsontheproliferationofiechinococcusgranulosusilarvalcells AT denegriguillermomaria effectofdifferentterpenecontainingessentialoilsontheproliferationofiechinococcusgranulosusilarvalcells AT elissondomariacelina effectofdifferentterpenecontainingessentialoilsontheproliferationofiechinococcusgranulosusilarvalcells |
| bdutipo_str |
Repositorios |
| _version_ |
1764820493055033349 |