Large-scale mapping of bioactive peptides in structural and sequence space

Health-enhancing potential bioactive peptide (BP) has driven an interest in food proteins as well as in the development of predictive methods. Research in this area has been especially active to use them as components in functional foods. Apparently, BPs do not have a given biological function in th...

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Autores principales: Nardo, Agustina Estefanía, Añón, María Cristina, Parisi, Gustavo Daniel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ingeniería Química
Bioactive peptides
Food
Superfolds
Hot-spots
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/98334
https://ri.conicet.gov.ar/11336/86386
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191063
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-98334
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ingeniería Química
Bioactive peptides
Food
Superfolds
Hot-spots
spellingShingle Ingeniería Química
Bioactive peptides
Food
Superfolds
Hot-spots
Nardo, Agustina Estefanía
Añón, María Cristina
Parisi, Gustavo Daniel
Large-scale mapping of bioactive peptides in structural and sequence space
topic_facet Ingeniería Química
Bioactive peptides
Food
Superfolds
Hot-spots
description Health-enhancing potential bioactive peptide (BP) has driven an interest in food proteins as well as in the development of predictive methods. Research in this area has been especially active to use them as components in functional foods. Apparently, BPs do not have a given biological function in the containing proteins and they do not evolve under independent evolutionary constraints. In this work we performed a large-scale mapping of BPs in sequence and structural space. Using well curated BP deposited in BIOPEP database, we searched for exact matches in non-redundant sequences databases. Proteins containing BPs, were used in fold-recognition methods to predict the corresponding folds and BPs occurrences were mapped. We found that fold distribution of BP occurrences possibly reflects sequence relative abundance in databases. However, we also found that proteins with 5 or more than 5 BP in their sequences correspond to well populated protein folds, called superfolds. Also, we found that in well populated superfamilies, BPs tend to adopt similar locations in the protein fold, suggesting the existence of hotspots. We think that our results could contribute to the development of new bioinformatics pipeline to improve BP detection.
format Articulo
Articulo
author Nardo, Agustina Estefanía
Añón, María Cristina
Parisi, Gustavo Daniel
author_facet Nardo, Agustina Estefanía
Añón, María Cristina
Parisi, Gustavo Daniel
author_sort Nardo, Agustina Estefanía
title Large-scale mapping of bioactive peptides in structural and sequence space
title_short Large-scale mapping of bioactive peptides in structural and sequence space
title_full Large-scale mapping of bioactive peptides in structural and sequence space
title_fullStr Large-scale mapping of bioactive peptides in structural and sequence space
title_full_unstemmed Large-scale mapping of bioactive peptides in structural and sequence space
title_sort large-scale mapping of bioactive peptides in structural and sequence space
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/98334
https://ri.conicet.gov.ar/11336/86386
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0191063
work_keys_str_mv AT nardoagustinaestefania largescalemappingofbioactivepeptidesinstructuralandsequencespace
AT anonmariacristina largescalemappingofbioactivepeptidesinstructuralandsequencespace
AT parisigustavodaniel largescalemappingofbioactivepeptidesinstructuralandsequencespace
bdutipo_str Repositorios
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