New Insights in Immunotherapies for Food Allergies : A Path between the Mouse Model and the Allergic Patient

Allergic diseases are the most prevalent immunopathologies worldwide. Nowadays, allergen avoidance is the unique effective treatment for allergic patients. Pre-clinical studies and clinical trials have been successful to prove that immunotherapies may accomplish mucosal mechanisms of allergen-specif...

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Detalles Bibliográficos
Autores principales: Smaldini, Paola Lorena, Docena, Guillermo Horacio
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Exactas
Ciencias Médicas
Food-allergy
Mouse-model
Immunotherapy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/98288
https://ri.conicet.gov.ar/11336/54449
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-98288
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Ciencias Médicas
Food-allergy
Mouse-model
Immunotherapy
spellingShingle Ciencias Exactas
Ciencias Médicas
Food-allergy
Mouse-model
Immunotherapy
Smaldini, Paola Lorena
Docena, Guillermo Horacio
New Insights in Immunotherapies for Food Allergies : A Path between the Mouse Model and the Allergic Patient
topic_facet Ciencias Exactas
Ciencias Médicas
Food-allergy
Mouse-model
Immunotherapy
description Allergic diseases are the most prevalent immunopathologies worldwide. Nowadays, allergen avoidance is the unique effective treatment for allergic patients. Pre-clinical studies and clinical trials have been successful to prove that immunotherapies may accomplish mucosal mechanisms of allergen-specific tolerance, which are able to revoke the allergic sensitization. Although more than 100 years have elapsed since the first reported procedure achieved in patients sensitive to pollen, the main obstacle in these therapies still remains adverse reactions induced during treatment. The need for further studies is required to explore safe and effective therapeutic protocols. More recently, immunotherapy appears to be an attractive option for patients with food allergy, although it is still experimental. Different strategies were proposed to overcome the concerning adverse effects that compromise safety, effectiveness and compliance with treatments. At this point, translational medicine is a flourish field in the arenas of basic science, applied science, and clinical research. The use of experimental animals may provide new insights to unravel mechanisms that play key roles in desensitization and tolerance induction, and to modify existing protocols or design new therapeutic approaches. The present reviews describes the different immunotherapies that are used in allergic patients, the promising immune interventions that are currently evaluated in clinical trials and the contributions that animal models may provide to improve the quality of treatments.
format Articulo
Comunicacion
author Smaldini, Paola Lorena
Docena, Guillermo Horacio
author_facet Smaldini, Paola Lorena
Docena, Guillermo Horacio
author_sort Smaldini, Paola Lorena
title New Insights in Immunotherapies for Food Allergies : A Path between the Mouse Model and the Allergic Patient
title_short New Insights in Immunotherapies for Food Allergies : A Path between the Mouse Model and the Allergic Patient
title_full New Insights in Immunotherapies for Food Allergies : A Path between the Mouse Model and the Allergic Patient
title_fullStr New Insights in Immunotherapies for Food Allergies : A Path between the Mouse Model and the Allergic Patient
title_full_unstemmed New Insights in Immunotherapies for Food Allergies : A Path between the Mouse Model and the Allergic Patient
title_sort new insights in immunotherapies for food allergies : a path between the mouse model and the allergic patient
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/98288
https://ri.conicet.gov.ar/11336/54449
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