A kinetic and mechanistic study on the thermal decomposition reactions of cis- and trans- fused 1,2,4-trioxanes
The kinetics of the thermal decomposition reactions of artemisinine (1), a cis-fused 1,2,4-trioxane, and trans-3,3dimethyl-1,2,4-trioxane (6) in solutions of benzene, toluene, and methanol in sealed tubes were compared at temperatures between 100.1° and 171.4 °C. Pseudo first-order rate constant val...
| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2003
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/98261 https://ri.conicet.gov.ar/11336/65056 https://dialnet.unirioja.es/servlet/articulo?codigo=2642748 |
| Aporte de: |
| id |
I19-R120-10915-98261 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Química Cis- and trans- fused 1,2,4-trioxanes Artemisinine Thermolysis Reactions kinetics Artemisinina Termófisis Cinética de reacción |
| spellingShingle |
Química Cis- and trans- fused 1,2,4-trioxanes Artemisinine Thermolysis Reactions kinetics Artemisinina Termófisis Cinética de reacción Cafferata, Lázaro F. R. Jeandupeax, Rene Romanelli, Gustavo Pablo Mateo, Carmen Margarita Jefford, Charles W. A kinetic and mechanistic study on the thermal decomposition reactions of cis- and trans- fused 1,2,4-trioxanes |
| topic_facet |
Química Cis- and trans- fused 1,2,4-trioxanes Artemisinine Thermolysis Reactions kinetics Artemisinina Termófisis Cinética de reacción |
| description |
The kinetics of the thermal decomposition reactions of artemisinine (1), a cis-fused 1,2,4-trioxane, and trans-3,3dimethyl-1,2,4-trioxane (6) in solutions of benzene, toluene, and methanol in sealed tubes were compared at temperatures between 100.1° and 171.4 °C. Pseudo first-order rate constant values were determined for conversions of both cyclic peroxides up to ca. 60%. The activation parameters and the composition of the reaction products were indicative of homolytic cleavage of their O-O bonds as the rate-determining steps followed by stepwise fragmentation. The free energies of activation (ΔG#) for 1 and 6 reactions in the aromatic solvents were calculated at the middle of each temperature range, giving values of 30.7 and 35.1 kcal/mol, respectively, which are evaluated considering their different molecular configurations. Furthermore, the rates of the thermal decomposition reactions of those trioxanes were sensitive to solvent effects. |
| format |
Articulo Articulo |
| author |
Cafferata, Lázaro F. R. Jeandupeax, Rene Romanelli, Gustavo Pablo Mateo, Carmen Margarita Jefford, Charles W. |
| author_facet |
Cafferata, Lázaro F. R. Jeandupeax, Rene Romanelli, Gustavo Pablo Mateo, Carmen Margarita Jefford, Charles W. |
| author_sort |
Cafferata, Lázaro F. R. |
| title |
A kinetic and mechanistic study on the thermal decomposition reactions of cis- and trans- fused 1,2,4-trioxanes |
| title_short |
A kinetic and mechanistic study on the thermal decomposition reactions of cis- and trans- fused 1,2,4-trioxanes |
| title_full |
A kinetic and mechanistic study on the thermal decomposition reactions of cis- and trans- fused 1,2,4-trioxanes |
| title_fullStr |
A kinetic and mechanistic study on the thermal decomposition reactions of cis- and trans- fused 1,2,4-trioxanes |
| title_full_unstemmed |
A kinetic and mechanistic study on the thermal decomposition reactions of cis- and trans- fused 1,2,4-trioxanes |
| title_sort |
kinetic and mechanistic study on the thermal decomposition reactions of cis- and trans- fused 1,2,4-trioxanes |
| publishDate |
2003 |
| url |
http://sedici.unlp.edu.ar/handle/10915/98261 https://ri.conicet.gov.ar/11336/65056 https://dialnet.unirioja.es/servlet/articulo?codigo=2642748 |
| work_keys_str_mv |
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| bdutipo_str |
Repositorios |
| _version_ |
1764820492879921153 |