Impact of A118G polymorphism on the Mu opioid receptor function in pain

Mu Opioid Receptor (MOR) activation by exogenous or endogenous agonists causes reduction of pain threshold after a noxious stimulus, relieving pain sensation.MOR is encoded by <i>OPRM1</i> gene and its messenger RNA suffers extensible modifications by alternative splicing an...

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Detalles Bibliográficos
Autores principales: López Soto, Eduardo Javier, Agosti, Francina, Catanesi, Cecilia Inés, Raingo, Jesica
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Medicina
Mu-opioid receptor
A118g polymorphism
N40d polymorphism
Voltage-gated calcium channel
Population studies
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/98211
https://ri.conicet.gov.ar/11336/85028
https://www.omicsonline.org/open-access/impact-of-ag-polymorphism-on-the-mu-opioid-receptor-function-in-pain-2167-0846.1000119.php?aid=15830
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-98211
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Mu-opioid receptor
A118g polymorphism
N40d polymorphism
Voltage-gated calcium channel
Population studies
spellingShingle Medicina
Mu-opioid receptor
A118g polymorphism
N40d polymorphism
Voltage-gated calcium channel
Population studies
López Soto, Eduardo Javier
Agosti, Francina
Catanesi, Cecilia Inés
Raingo, Jesica
Impact of A118G polymorphism on the Mu opioid receptor function in pain
topic_facet Medicina
Mu-opioid receptor
A118g polymorphism
N40d polymorphism
Voltage-gated calcium channel
Population studies
description Mu Opioid Receptor (MOR) activation by exogenous or endogenous agonists causes reduction of pain threshold after a noxious stimulus, relieving pain sensation.MOR is encoded by <i>OPRM1</i> gene and its messenger RNA suffers extensible modifications by alternative splicing and single nucleotide polymorphisms (SNPs). A118G (N40D) is the most frequent encoding MOR SNP in humans. In this review we discuss the impact of this polymorphism at molecular, cellular and clinical levels. Since some SNPs are unequally distributed among human populations, we also discuss the utility of A118G as an ethnicity marker among worldwide human populations. As an example, we evaluate A118G frequency in an Argentinean humanpopulation and compare it with worldwide frequencies extracted from HapMap database.
format Articulo
Articulo
author López Soto, Eduardo Javier
Agosti, Francina
Catanesi, Cecilia Inés
Raingo, Jesica
author_facet López Soto, Eduardo Javier
Agosti, Francina
Catanesi, Cecilia Inés
Raingo, Jesica
author_sort López Soto, Eduardo Javier
title Impact of A118G polymorphism on the Mu opioid receptor function in pain
title_short Impact of A118G polymorphism on the Mu opioid receptor function in pain
title_full Impact of A118G polymorphism on the Mu opioid receptor function in pain
title_fullStr Impact of A118G polymorphism on the Mu opioid receptor function in pain
title_full_unstemmed Impact of A118G polymorphism on the Mu opioid receptor function in pain
title_sort impact of a118g polymorphism on the mu opioid receptor function in pain
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/98211
https://ri.conicet.gov.ar/11336/85028
https://www.omicsonline.org/open-access/impact-of-ag-polymorphism-on-the-mu-opioid-receptor-function-in-pain-2167-0846.1000119.php?aid=15830
work_keys_str_mv AT lopezsotoeduardojavier impactofa118gpolymorphismonthemuopioidreceptorfunctioninpain
AT agostifrancina impactofa118gpolymorphismonthemuopioidreceptorfunctioninpain
AT catanesiceciliaines impactofa118gpolymorphismonthemuopioidreceptorfunctioninpain
AT raingojesica impactofa118gpolymorphismonthemuopioidreceptorfunctioninpain
bdutipo_str Repositorios
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