Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole

The experiments described here were designed to characterize the status of susceptibility/resistance to albendazole (ABZ) and triclabendazole (TCBZ) of a Fasciola hepatica isolate (named CEDIVE isolate) recovered from infected sheep (Gualeguay, Argentina) and maintained under laboratory conditions....

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Autores principales: Sanabria, Rodrigo Eduardo Fabrizio, Ceballos, Laura, Moreno, Laura, Romero, Jorge, Lanusse, Carlos E., Álvarez, Luis Ignacio
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Veterinarias
Fasciola hepatica isolate
Resistance
Albendazole
Triclabendazole
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/98200
https://ri.conicet.gov.ar/11336/992
http://www.ncbi.nlm.nih.gov/pubmed/23273779
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-98200
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Fasciola hepatica isolate
Resistance
Albendazole
Triclabendazole
spellingShingle Ciencias Veterinarias
Fasciola hepatica isolate
Resistance
Albendazole
Triclabendazole
Sanabria, Rodrigo Eduardo Fabrizio
Ceballos, Laura
Moreno, Laura
Romero, Jorge
Lanusse, Carlos E.
Álvarez, Luis Ignacio
Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole
topic_facet Ciencias Veterinarias
Fasciola hepatica isolate
Resistance
Albendazole
Triclabendazole
description The experiments described here were designed to characterize the status of susceptibility/resistance to albendazole (ABZ) and triclabendazole (TCBZ) of a Fasciola hepatica isolate (named CEDIVE isolate) recovered from infected sheep (Gualeguay, Argentina) and maintained under laboratory conditions. Two separate clinical efficacy experiments were performed on sheep artificially infected with the CEDIVE isolate. Experiment 1: Sheep were randomly distributed either in an untreated control group or an ABZ (7.5 mg/kg) treated group (n= 4 each). Additionally, the systemic exposure of ABZ metabolites was assessed in those ABZ-treated infected animals. In Experiment 2, an untreated control group and a TCBZ (10 mg/kg) treated group was included (n = 4 each). The fluckicidal efficacy of ABZ and TCBZ was assessed by comparison of the number of flukes recovered from untreated and treated sheep at 15 days post-treatment. The efficacy against the CEDIVE isolate of F. hepatica was 29% (ABZ) and 100% (TCBZ). The plasma drug exposure (expressed as AUC and Cmax) observed in the ABZ treated animals (Experiment 1), was in agreement with data obtained in previous studies, which indicate that the low ABZ efficacy was not related to the quality of the pharmaceutical product and/or to a low systemic availability of the active drug/metabolite. The results reported here, clearly show that the CEDIVE isolate of F. hepatica behaves as resistant to ABZ and susceptible to TCBZ.
format Articulo
Preprint
author Sanabria, Rodrigo Eduardo Fabrizio
Ceballos, Laura
Moreno, Laura
Romero, Jorge
Lanusse, Carlos E.
Álvarez, Luis Ignacio
author_facet Sanabria, Rodrigo Eduardo Fabrizio
Ceballos, Laura
Moreno, Laura
Romero, Jorge
Lanusse, Carlos E.
Álvarez, Luis Ignacio
author_sort Sanabria, Rodrigo Eduardo Fabrizio
title Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole
title_short Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole
title_full Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole
title_fullStr Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole
title_full_unstemmed Identification of a field isolate of Fasciola hepatica resistant to albendazole and susceptible to triclabendazole
title_sort identification of a field isolate of fasciola hepatica resistant to albendazole and susceptible to triclabendazole
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/98200
https://ri.conicet.gov.ar/11336/992
http://www.ncbi.nlm.nih.gov/pubmed/23273779
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