Intestinal antispasmodic effects of three Argentinian plants: Hypericum connatum, Berberis ruscifolia and Cecropia pachystachya: mechanisms of action and comparison with the effects of Brugmansia arborea

Some medicinal plants are used in Argentina to reduce gastrointestinal symptoms as antispasmodics, but notall these effects were validated. This work studied the effects of three native plants as the ethanolic tinctures(T) of Hypericum connatum and Berberis ruscifolia, as well as the acqueous crude...

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Detalles Bibliográficos
Autores principales:	Matera, Soledad Inés, Bruno, Fiorella Gianina, Pérez, Vanina Andrea, Querini, C. A., Ragone, María Inés, Consolini, Alicia Elvira, Bayley Agnoli, Matías
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Biología <i>Hypericum connatum</i> <i>Berberis ruscifolia</i> <i>Cecropia pachystachya</i> <i>Brugmansia arborea</i> Antispasmodic Ca2+-blockade Sedative
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/97939 https://ri.conicet.gov.ar/11336/55929 http://pharmacologyonline.silae.it/files/archives/2016/vol2/PhOL_2016_2_A013_Matera_91_99.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-97939
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Biología <i>Hypericum connatum</i> <i>Berberis ruscifolia</i> <i>Cecropia pachystachya</i> <i>Brugmansia arborea</i> Antispasmodic Ca2+-blockade Sedative
spellingShingle	Biología <i>Hypericum connatum</i> <i>Berberis ruscifolia</i> <i>Cecropia pachystachya</i> <i>Brugmansia arborea</i> Antispasmodic Ca2+-blockade Sedative Matera, Soledad Inés Bruno, Fiorella Gianina Pérez, Vanina Andrea Querini, C. A. Ragone, María Inés Consolini, Alicia Elvira Bayley Agnoli, Matías Intestinal antispasmodic effects of three Argentinian plants: <i>Hypericum connatum</i>, <i>Berberis ruscifolia</i> and <i>Cecropia pachystachya</i>: mechanisms of action and comparison with the effects of <i>Brugmansia arborea</i>
topic_facet	Biología <i>Hypericum connatum</i> <i>Berberis ruscifolia</i> <i>Cecropia pachystachya</i> <i>Brugmansia arborea</i> Antispasmodic Ca2+-blockade Sedative
description	Some medicinal plants are used in Argentina to reduce gastrointestinal symptoms as antispasmodics, but notall these effects were validated. This work studied the effects of three native plants as the ethanolic tinctures(T) of Hypericum connatum and Berberis ruscifolia, as well as the acqueous crude extracts (A.c.e) of Cecropiapachystachya, and compared the mechanisms with those of the peruvian plant Brugmansia arborea inisolated rat intestines. The first three plants demonstrated to have antispasmodic effect mainly due to thenon-competitive blockade of the agonist-induced contraction and calcium influx to the smooth muscle,which was associated to the presence of flavonoids. H. connatum also induced the release of prostaglandinswhich cause intestinal contraction, and NO which cause peristalsis, in a way that the blockade of bothmechanisms potentiated the relaxant effect of the T-H.c. In contrast, the A.c.e of Brugmansia arboreashowed to be a competitive antagonist of muscarinic receptors in the isolated intestine, in agreement withthe presence of tropane alkaloids. Moreover, H. connatum and C. pachystachya also produced certainsedation, which could contribute to the antispasmodic effect. The tincture of Hypericum connatum, but notthat of Berberis ruscifolia, reduced the spontaneous locomotion and exploration of mice in the open-fieldtest, at doses of 200 mg leaves/Kg. Results suggest that the three native plants exhibited an importantantispasmodic effect mainly due to non-competitive antagonism of the agonist and of Ca2+-influx to smoothmuscle.
format	Articulo Articulo
author	Matera, Soledad Inés Bruno, Fiorella Gianina Pérez, Vanina Andrea Querini, C. A. Ragone, María Inés Consolini, Alicia Elvira Bayley Agnoli, Matías
author_facet	Matera, Soledad Inés Bruno, Fiorella Gianina Pérez, Vanina Andrea Querini, C. A. Ragone, María Inés Consolini, Alicia Elvira Bayley Agnoli, Matías
author_sort	Matera, Soledad Inés
title	Intestinal antispasmodic effects of three Argentinian plants: <i>Hypericum connatum</i>, <i>Berberis ruscifolia</i> and <i>Cecropia pachystachya</i>: mechanisms of action and comparison with the effects of <i>Brugmansia arborea</i>
title_short	Intestinal antispasmodic effects of three Argentinian plants: <i>Hypericum connatum</i>, <i>Berberis ruscifolia</i> and <i>Cecropia pachystachya</i>: mechanisms of action and comparison with the effects of <i>Brugmansia arborea</i>
title_full	Intestinal antispasmodic effects of three Argentinian plants: <i>Hypericum connatum</i>, <i>Berberis ruscifolia</i> and <i>Cecropia pachystachya</i>: mechanisms of action and comparison with the effects of <i>Brugmansia arborea</i>
title_fullStr	Intestinal antispasmodic effects of three Argentinian plants: <i>Hypericum connatum</i>, <i>Berberis ruscifolia</i> and <i>Cecropia pachystachya</i>: mechanisms of action and comparison with the effects of <i>Brugmansia arborea</i>
title_full_unstemmed	Intestinal antispasmodic effects of three Argentinian plants: <i>Hypericum connatum</i>, <i>Berberis ruscifolia</i> and <i>Cecropia pachystachya</i>: mechanisms of action and comparison with the effects of <i>Brugmansia arborea</i>
title_sort	intestinal antispasmodic effects of three argentinian plants: <i>hypericum connatum</i>, <i>berberis ruscifolia</i> and <i>cecropia pachystachya</i>: mechanisms of action and comparison with the effects of <i>brugmansia arborea</i>
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/97939 https://ri.conicet.gov.ar/11336/55929 http://pharmacologyonline.silae.it/files/archives/2016/vol2/PhOL_2016_2_A013_Matera_91_99.pdf
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Intestinal antispasmodic effects of three Argentinian plants: <i>Hypericum connatum</i>, <i>Berberis ruscifolia</i> and <i>Cecropia pachystachya</i>: mechanisms of action and comparison with the effects of <i>Brugmansia arborea</i>

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