Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability

Responsive interfacial architectures of practical interest commonly require the combination of conflicting properties in terms of their demand upon material structure. Switchable stiffness, wettability, and permeability, key features for tissue engineering applications, are in fact known to be exclu...

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Autores principales: Maza, Eliana María, Bilderling, Catalina von, Cortez, María Lorena, Díaz, Gisela, Bianchi, Micaela, Pietrasanta, Lia, Giussi, Juan Martín, Azzaroni, Omar
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2018
Materias:
Química
Thermo-responsive microgels
Nanoarchitectonic approach
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/97920
https://ri.conicet.gov.ar/11336/88728
http://pubs.acs.org/doi/10.1021/acs.langmuir.8b00047
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-97920
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Thermo-responsive microgels
Nanoarchitectonic approach
spellingShingle Química
Thermo-responsive microgels
Nanoarchitectonic approach
Maza, Eliana María
Bilderling, Catalina von
Cortez, María Lorena
Díaz, Gisela
Bianchi, Micaela
Pietrasanta, Lia
Giussi, Juan Martín
Azzaroni, Omar
Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
topic_facet Química
Thermo-responsive microgels
Nanoarchitectonic approach
description Responsive interfacial architectures of practical interest commonly require the combination of conflicting properties in terms of their demand upon material structure. Switchable stiffness, wettability, and permeability, key features for tissue engineering applications, are in fact known to be exclusively interdependent. Here, we present a nanoarchitectonic approach that decouples these divergent properties by the use of thermoresponsive microgels as building blocks for the construction of three-dimensional arrays of interconnected pores. Layer-by-layer assembled poly(N-isopropylacrylamide-co-methacrylic acid) microgel films were found to exhibit an increase in hydrophobicity, stiffness, and adhesion properties upon switching the temperature from below to above the lower critical solution temperature, whereas the permeability of redox probes through the film remained unchanged. Our findings indicate that the switch in hydrophilicity and nanomechanical properties undergone by the microgels does not compromise the porosity of the film, thus allowing the free diffusion of redox probes through the polymer-free volume of the submicrometer pores. This novel approach for decoupling conflicting properties provides a strategic route for creating tailorable scaffolds with unforeseen functionalities.
format Articulo
Preprint
author Maza, Eliana María
Bilderling, Catalina von
Cortez, María Lorena
Díaz, Gisela
Bianchi, Micaela
Pietrasanta, Lia
Giussi, Juan Martín
Azzaroni, Omar
author_facet Maza, Eliana María
Bilderling, Catalina von
Cortez, María Lorena
Díaz, Gisela
Bianchi, Micaela
Pietrasanta, Lia
Giussi, Juan Martín
Azzaroni, Omar
author_sort Maza, Eliana María
title Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_short Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_full Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_fullStr Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_full_unstemmed Layer-by-Layer Assembled Microgels Can Combine Conflicting Properties: Switchable Stiffness and Wettability without Affecting Permeability
title_sort layer-by-layer assembled microgels can combine conflicting properties: switchable stiffness and wettability without affecting permeability
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/97920
https://ri.conicet.gov.ar/11336/88728
http://pubs.acs.org/doi/10.1021/acs.langmuir.8b00047
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