A role for ΔfosB in calorie restriction-induced metabolic changes
Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcript...
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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Articulo Preprint |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/97493 https://ri.conicet.gov.ar/11336/85917 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125466/ |
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I19-R120-10915-97493 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Bioquímica Appetite Feeding Metabolism Nucleus accumbens Orexin |
| spellingShingle |
Bioquímica Appetite Feeding Metabolism Nucleus accumbens Orexin Vialou, Vincent F. Cui, Huxing Perelló, Mario Mahgoub, Melissa A. Yu, Hana G. Rush, Augustus J. Pranav, Heena Jung, Saendy Yangisawa, Masashi Zigman, Jeffrey M. Elmquist, Joel K. Nestler, Eric J. Lutter, Michael A role for ΔfosB in calorie restriction-induced metabolic changes |
| topic_facet |
Bioquímica Appetite Feeding Metabolism Nucleus accumbens Orexin |
| description |
Background: Calorie restriction (CR) induces long-term changes in motivation to eat highly palatable food and, in body weight regulation, through an unknown mechanism. Methods: After a period of CR and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ΔFosB. The ΔFosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, and behavioral and metabolic studies were conducted. Results: We show that accumulation of ΔFosB in the NAc shell after CR in mice corresponds to a period of increased motivation for high fat reward and reduced energy expenditure. Furthermore, ΔFosB overexpression in this region increases instrumental responding for a high fat reward via an orexin-dependent mechanism while also decreasing energy expenditure and promoting adiposity. Conclusions: These results suggest that ΔFosB signaling in NAc mediates adaptive responses to CR. |
| format |
Articulo Preprint |
| author |
Vialou, Vincent F. Cui, Huxing Perelló, Mario Mahgoub, Melissa A. Yu, Hana G. Rush, Augustus J. Pranav, Heena Jung, Saendy Yangisawa, Masashi Zigman, Jeffrey M. Elmquist, Joel K. Nestler, Eric J. Lutter, Michael |
| author_facet |
Vialou, Vincent F. Cui, Huxing Perelló, Mario Mahgoub, Melissa A. Yu, Hana G. Rush, Augustus J. Pranav, Heena Jung, Saendy Yangisawa, Masashi Zigman, Jeffrey M. Elmquist, Joel K. Nestler, Eric J. Lutter, Michael |
| author_sort |
Vialou, Vincent F. |
| title |
A role for ΔfosB in calorie restriction-induced metabolic changes |
| title_short |
A role for ΔfosB in calorie restriction-induced metabolic changes |
| title_full |
A role for ΔfosB in calorie restriction-induced metabolic changes |
| title_fullStr |
A role for ΔfosB in calorie restriction-induced metabolic changes |
| title_full_unstemmed |
A role for ΔfosB in calorie restriction-induced metabolic changes |
| title_sort |
role for δfosb in calorie restriction-induced metabolic changes |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/97493 https://ri.conicet.gov.ar/11336/85917 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125466/ |
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