Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening
Doxycycline (DOX), tetracycline of second generation, is mainly active against Gram–positive and Gram–negative bacteria, aerobic and anaerobic. Although there are few pharmacokinetic studies in chickens, it is frequently used for the colibacillosis treatment, salmonellosis, staphylococcal infections...
| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2018
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/96825 https://ri.conicet.gov.ar/11336/86329 https://medcraveonline.com/IJAWB/IJAWB-03-00095.php |
| Aporte de: |
| id |
I19-R120-10915-96825 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Veterinarias Antimicrobials Doxycycline Poultry Tissues Residues Withdrawal time |
| spellingShingle |
Ciencias Veterinarias Antimicrobials Doxycycline Poultry Tissues Residues Withdrawal time Mestorino, Olga Nora Zeinsteger, Pedro Adolfo Buchamer, Andrea Verónica Buldain, Daniel Cornelio Aliverti, Florencia Marchetti, María Laura Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening |
| topic_facet |
Ciencias Veterinarias Antimicrobials Doxycycline Poultry Tissues Residues Withdrawal time |
| description |
Doxycycline (DOX), tetracycline of second generation, is mainly active against Gram–positive and Gram–negative bacteria, aerobic and anaerobic. Although there are few pharmacokinetic studies in chickens, it is frequently used for the colibacillosis treatment, salmonellosis, staphylococcal infections, avian mycoplasmosis and chlamydia. The objective of this study was to evaluate the withdrawal time (WT) of DOX formulation at 25 % in edible tissues, after its oral (PO) use in broilers. Forty healthy chicks (30–35 days of age) were used. DOX was administered with drinking water for 5 days at 10 mg kg–1 (N = 36); four untreated animals were reserved (control). Six animals per group were euthanized by cervical dislocation after desensitization by passage of an electric current through the head, after 24 hours until 9 d post treatment and control animals also. Muscle, liver, kidney and skin/fat samples were obtained. DOX was determined by HPLC with UV detection. DOX concentrations were determined in all tissues examined; generally falling below the MRL at 7 d after administration is terminated. It was estimated 6.58, 8.18, 8.69 and 6.96 d of WT for muscle, liver, kidney and skin/fat, respectively. After DOX administration at a rate of 10 mg kg–1 for 5 days in drinking water, a WT of 9 d is suggested in poultry destined for human consumption. |
| format |
Articulo Articulo |
| author |
Mestorino, Olga Nora Zeinsteger, Pedro Adolfo Buchamer, Andrea Verónica Buldain, Daniel Cornelio Aliverti, Florencia Marchetti, María Laura |
| author_facet |
Mestorino, Olga Nora Zeinsteger, Pedro Adolfo Buchamer, Andrea Verónica Buldain, Daniel Cornelio Aliverti, Florencia Marchetti, María Laura |
| author_sort |
Mestorino, Olga Nora |
| title |
Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening |
| title_short |
Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening |
| title_full |
Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening |
| title_fullStr |
Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening |
| title_full_unstemmed |
Tissue depletion of doxycycline after its oral administration in food producing chicken for fattening |
| title_sort |
tissue depletion of doxycycline after its oral administration in food producing chicken for fattening |
| publishDate |
2018 |
| url |
http://sedici.unlp.edu.ar/handle/10915/96825 https://ri.conicet.gov.ar/11336/86329 https://medcraveonline.com/IJAWB/IJAWB-03-00095.php |
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AT mestorinoolganora tissuedepletionofdoxycyclineafteritsoraladministrationinfoodproducingchickenforfattening AT zeinstegerpedroadolfo tissuedepletionofdoxycyclineafteritsoraladministrationinfoodproducingchickenforfattening AT buchamerandreaveronica tissuedepletionofdoxycyclineafteritsoraladministrationinfoodproducingchickenforfattening AT buldaindanielcornelio tissuedepletionofdoxycyclineafteritsoraladministrationinfoodproducingchickenforfattening AT alivertiflorencia tissuedepletionofdoxycyclineafteritsoraladministrationinfoodproducingchickenforfattening AT marchettimarialaura tissuedepletionofdoxycyclineafteritsoraladministrationinfoodproducingchickenforfattening |
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Repositorios |
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1764820492489850883 |