Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis

The nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD encompasses a wide histological spectrum ranging from benign simple steatosis to non-Alcoholic steatohepatitis (NASH). Sustained inflammation in the liver is critical in this process. Hepatic m...

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Autores principales:	Chackelevicius, Carla Melisa, Gambaro, Sabrina Eliana, Tiribelli, Claudio, Rosso, Natalia
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Ciencias Médicas Inflammation Interleukin-17 Non-alcoholic steatohepatitis Nonalcoholic fatty liver disease Th17
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/96722 https://ri.conicet.gov.ar/11336/62898 https://www.wjgnet.com/1007-9327/full/v22/i41/9096.htm
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-96722
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Inflammation Interleukin-17 Non-alcoholic steatohepatitis Nonalcoholic fatty liver disease Th17
spellingShingle	Ciencias Médicas Inflammation Interleukin-17 Non-alcoholic steatohepatitis Nonalcoholic fatty liver disease Th17 Chackelevicius, Carla Melisa Gambaro, Sabrina Eliana Tiribelli, Claudio Rosso, Natalia Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
topic_facet	Ciencias Médicas Inflammation Interleukin-17 Non-alcoholic steatohepatitis Nonalcoholic fatty liver disease Th17
description	The nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD encompasses a wide histological spectrum ranging from benign simple steatosis to non-Alcoholic steatohepatitis (NASH). Sustained inflammation in the liver is critical in this process. Hepatic macrophages, including liver resident macropaghes (Kupffer cells), monocytes infiltrating the injured liver, as well as specific lymphocytes subsets play a pivotal role in the initiation and perpetuation of the inflammatory response, with a major deleterious impact on the progression of fatty liver to fibrosis. During the last years, Th17 cells have been involved in the development of inflammation not only in liver but also in other organs, such as adipose tissue or lung. Differentiation of a naïve T cell into a Th17 cell leads to pro-inflammatory cytokine and chemokine production with subsequent myeloid cell recruitment to the inflamed tissue. Th17 response can be mitigated by T regulatory cells that secrete anti-inflammatory cytokines. Both T cell subsets need TGF-β for their differentiation and a characteristic plasticity in their phenotype may render them new therapeutic targets. In this review, we discuss the role of the Th17 pathway in NAFLD progression to NASH and to liver fibrosis analyzing different animal models of liver injury and human studies.
format	Articulo Articulo
author	Chackelevicius, Carla Melisa Gambaro, Sabrina Eliana Tiribelli, Claudio Rosso, Natalia
author_facet	Chackelevicius, Carla Melisa Gambaro, Sabrina Eliana Tiribelli, Claudio Rosso, Natalia
author_sort	Chackelevicius, Carla Melisa
title	Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
title_short	Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
title_full	Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
title_fullStr	Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
title_full_unstemmed	Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
title_sort	th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/96722 https://ri.conicet.gov.ar/11336/62898 https://www.wjgnet.com/1007-9327/full/v22/i41/9096.htm
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bdutipo_str	Repositorios
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Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis

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