Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects

I have been involved in research on polyunsaturated fatty acids since 1964 and this review is intended to cover some of the most important aspects of this work. Polyunsaturated fatty acids have followed me duringmy whole scientific career and I have published a number of studies concerned with diffe...

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Autor principal: Catalá, Ángel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Exactas
Química
Polyunsaturated fatty acids
Desaturases
Lipid peroxidation
Antioxidants
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/96685
https://ri.conicet.gov.ar/11336/4775
http://www.hindawi.com/journals/jl/aip/710290/
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-96685
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
Polyunsaturated fatty acids
Desaturases
Lipid peroxidation
Antioxidants
spellingShingle Ciencias Exactas
Química
Polyunsaturated fatty acids
Desaturases
Lipid peroxidation
Antioxidants
Catalá, Ángel
Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects
topic_facet Ciencias Exactas
Química
Polyunsaturated fatty acids
Desaturases
Lipid peroxidation
Antioxidants
description I have been involved in research on polyunsaturated fatty acids since 1964 and this review is intended to cover some of the most important aspects of this work. Polyunsaturated fatty acids have followed me duringmy whole scientific career and I have published a number of studies concerned with different aspects of them such as chemical synthesis, enzymatic formation, metabolism, transport, physical, chemical, and catalytic properties of a reconstructed desaturase system in liposomes, lipid peroxidation, and their effects. The first project I became involved in was the organic synthesis of [1-<sup>14</sup>C] eicosa-11,14-dienoic acid, with the aim of demonstrating the participation of that compound as a possible intermediary in the biosynthesis of arachidonic acid "in vivo". From 1966 to 1982, I was involved in several projects that study the metabolism of polyunsaturated fatty acids. In the eighties, we studied fatty acid binding protein. From 1990 up to now, our laboratory has been interested in the lipid peroxidation of biological membranes from various tissues and different species as well as liposomes prepared with phospholipids rich in PUFAs. We tested the effect of many antioxidants such as alpha tocopherol, vitamin A, melatonin and its structural analogues, and conjugated linoleic acid, among others.
format Articulo
Articulo
author Catalá, Ángel
author_facet Catalá, Ángel
author_sort Catalá, Ángel
title Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects
title_short Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects
title_full Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects
title_fullStr Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects
title_full_unstemmed Five Decades with Polyunsaturated Fatty Acids: Chemical Synthesis, Enzymatic Formation, Lipid Peroxidation and Its Biological Effects
title_sort five decades with polyunsaturated fatty acids: chemical synthesis, enzymatic formation, lipid peroxidation and its biological effects
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/96685
https://ri.conicet.gov.ar/11336/4775
http://www.hindawi.com/journals/jl/aip/710290/
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