State of the Art on Food Allergy Immunotherapy

Food allergy is increasing in prevalence in westernized countries, leading to significant morbidity including nutritional deficiencies and the potential for fatal anaphylaxis during accidental exposure to the allergen. The current treatment remains strict avoidance, although the disease is not cured...

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Detalles Bibliográficos
Autores principales: Smaldini, Paola Lorena, Docena, Guillermo Horacio
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Exactas
Ciencias Médicas
Immunotherapy
Food-allergy
Tolerance
Desensitization
IgE
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/96457
https://ri.conicet.gov.ar/11336/58009
https://clinmedjournals.org/articles/ijam/international-journal-of-allergy-medications-ijam-2-015.php?jid=ijam
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-96457
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Ciencias Médicas
Immunotherapy
Food-allergy
Tolerance
Desensitization
IgE
spellingShingle Ciencias Exactas
Ciencias Médicas
Immunotherapy
Food-allergy
Tolerance
Desensitization
IgE
Smaldini, Paola Lorena
Docena, Guillermo Horacio
State of the Art on Food Allergy Immunotherapy
topic_facet Ciencias Exactas
Ciencias Médicas
Immunotherapy
Food-allergy
Tolerance
Desensitization
IgE
description Food allergy is increasing in prevalence in westernized countries, leading to significant morbidity including nutritional deficiencies and the potential for fatal anaphylaxis during accidental exposure to the allergen. The current treatment remains strict avoidance, although the disease is not cured. Allergen specific immunotherapy for food allergy is currently being actively evaluated, but is still experimental. Nevertheless, it is the only disease-modifying therapy for IgE-mediated food allergy and appears to be a promising method of desensitization and tolerance achievement. Despite the success of different protocols studied in clinical trials (oral, sublingual and epicutaneous immunotherapy), the main drawback is the appearance of adverse reactions, which impacts in the patient adherence to the treatment. The mechanisms underlying successful food desensitization are also unclear, in part because there is no standard immunotherapy protocol and different mechanisms have been proposed. The treatment variations currently being investigated increases the likelihood of finding novel or modified therapies for food allergy. In this regard, mouse models of experimental allergy constitute a valuable biological tool to elucidate and understand these mechanisms, and to evaluate novel therapeutic strategies.
format Articulo
Comunicacion
author Smaldini, Paola Lorena
Docena, Guillermo Horacio
author_facet Smaldini, Paola Lorena
Docena, Guillermo Horacio
author_sort Smaldini, Paola Lorena
title State of the Art on Food Allergy Immunotherapy
title_short State of the Art on Food Allergy Immunotherapy
title_full State of the Art on Food Allergy Immunotherapy
title_fullStr State of the Art on Food Allergy Immunotherapy
title_full_unstemmed State of the Art on Food Allergy Immunotherapy
title_sort state of the art on food allergy immunotherapy
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/96457
https://ri.conicet.gov.ar/11336/58009
https://clinmedjournals.org/articles/ijam/international-journal-of-allergy-medications-ijam-2-015.php?jid=ijam
work_keys_str_mv AT smaldinipaolalorena stateoftheartonfoodallergyimmunotherapy
AT docenaguillermohoracio stateoftheartonfoodallergyimmunotherapy
bdutipo_str Repositorios
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