Estudio de la dinámica de agregación proteica con TRP-cage

In this work we propose a domain decomposition method based on Robin type boundary con- ditions that is suitable to solve the porous media equations on very large reservoirs. In order to reduce the algebraic systems to be solved to affordable sizes, a multiscale formulation is considered in which th...

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Detalles Bibliográficos
Autores principales: Faundez, Cristian Leonel, Meyra, Ariel Germán, Ferrara, Carlos Gastón
Formato: Articulo
Lenguaje:Español
Publicado: 2018
Materias:
Bioquímica
Proteínas
TRP-cage
Superficie Accesible al Solvente (SASA)
Proteins
Solvent Accessible Surface (SASA)
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/96208
https://ri.conicet.gov.ar/11336/89284
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-96208
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Bioquímica
Proteínas
TRP-cage
Superficie Accesible al Solvente (SASA)
Proteins
Solvent Accessible Surface (SASA)
spellingShingle Bioquímica
Proteínas
TRP-cage
Superficie Accesible al Solvente (SASA)
Proteins
Solvent Accessible Surface (SASA)
Faundez, Cristian Leonel
Meyra, Ariel Germán
Ferrara, Carlos Gastón
Estudio de la dinámica de agregación proteica con TRP-cage
topic_facet Bioquímica
Proteínas
TRP-cage
Superficie Accesible al Solvente (SASA)
Proteins
Solvent Accessible Surface (SASA)
description In this work we propose a domain decomposition method based on Robin type boundary con- ditions that is suitable to solve the porous media equations on very large reservoirs. In order to reduce the algebraic systems to be solved to affordable sizes, a multiscale formulation is considered in which the coupling variables between subdomains, namely, pressures and normal fluxes, are seek in low dimen- sional spaces on the skeleton of the decomposition, while considering the permeability heterogeneities in the original fine grid for the local problems. In the new formulation, a non-dimensional parameter in the Robin condition is introduced such that we may transit smoothly from two well known formulations, namely, the Multiscale Mortar Mixed and the Multiscale Hybrid Mixed finite element methods. In the proposed formulation the interface spaces for pressure and fluxes can be selected independently. This has the potential to produce more accurate results by better accommodating local features of the exact solution near subdomain boundaries. Several numerical examples which exhibit highly heterogeneous permeability fields and channelized regions are solved with the new formulation and results compared to the aforementioned multiscale methods.
format Articulo
Articulo
author Faundez, Cristian Leonel
Meyra, Ariel Germán
Ferrara, Carlos Gastón
author_facet Faundez, Cristian Leonel
Meyra, Ariel Germán
Ferrara, Carlos Gastón
author_sort Faundez, Cristian Leonel
title Estudio de la dinámica de agregación proteica con TRP-cage
title_short Estudio de la dinámica de agregación proteica con TRP-cage
title_full Estudio de la dinámica de agregación proteica con TRP-cage
title_fullStr Estudio de la dinámica de agregación proteica con TRP-cage
title_full_unstemmed Estudio de la dinámica de agregación proteica con TRP-cage
title_sort estudio de la dinámica de agregación proteica con trp-cage
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/96208
https://ri.conicet.gov.ar/11336/89284
work_keys_str_mv AT faundezcristianleonel estudiodeladinamicadeagregacionproteicacontrpcage
AT meyraarielgerman estudiodeladinamicadeagregacionproteicacontrpcage
AT ferraracarlosgaston estudiodeladinamicadeagregacionproteicacontrpcage
AT faundezcristianleonel studyofproteinaggregationdynamicswithtrpcage
AT meyraarielgerman studyofproteinaggregationdynamicswithtrpcage
AT ferraracarlosgaston studyofproteinaggregationdynamicswithtrpcage
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