Estabilidad térmica en endoperoxidos en solución: Ascaridol

The importance of cyclic peroxides as the substituted I ,2,4-trioxanes, 1,2,4,5-tetroxanes and endoperoxides has grown considerably in recent years ever since the naturally occurring trioxanc artemisinine and some of its dcrivatives achievcd prominence as potent antimalarial agents. Physical proper...

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Detalles Bibliográficos
Autores principales: Jeandupex, Rene, Romanelli, Gustavo Pablo, Cafferata, Lázaro F. R.
Formato: Articulo
Lenguaje:Español
Publicado: 2002
Materias:
Química
Endoperoxides-ascaridole
Thermal stability
Atimalarial agents
Endoperóxidos
Ascaridol
Estabilidad termica
Antimaláricos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/96089
https://ri.conicet.gov.ar/11336/63652
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-96089
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Química
Endoperoxides-ascaridole
Thermal stability
Atimalarial agents
Endoperóxidos
Ascaridol
Estabilidad termica
Antimaláricos
spellingShingle Química
Endoperoxides-ascaridole
Thermal stability
Atimalarial agents
Endoperóxidos
Ascaridol
Estabilidad termica
Antimaláricos
Jeandupex, Rene
Romanelli, Gustavo Pablo
Cafferata, Lázaro F. R.
Estabilidad térmica en endoperoxidos en solución: Ascaridol
topic_facet Química
Endoperoxides-ascaridole
Thermal stability
Atimalarial agents
Endoperóxidos
Ascaridol
Estabilidad termica
Antimaláricos
description The importance of cyclic peroxides as the substituted I ,2,4-trioxanes, 1,2,4,5-tetroxanes and endoperoxides has grown considerably in recent years ever since the naturally occurring trioxanc artemisinine and some of its dcrivatives achievcd prominence as potent antimalarial agents. Physical properties reported for ascaridole, a cyclic endoperoxide isolated from the vegetal named Paico and also from synthetic procedures by photoxygenation of a-tcrpinene, are significantly differents. This lead lo perform the preparation of that substance by Schenck's method, but working al OºC and doing its separalion and purification al room tcmperature by preparative column chromatography .. Excelcnt yields of ascaridol were obtained (ca. 80 % GCFID) of high degree of purity (>98 %, GC; RPHPLC; NMR, 1H, 13C). The thermal stability of ascaridole in solution is advanced, reporting the activation parameters values for the unimolecular decomposition of that substance in isopropyl alcohol.
format Articulo
Articulo
author Jeandupex, Rene
Romanelli, Gustavo Pablo
Cafferata, Lázaro F. R.
author_facet Jeandupex, Rene
Romanelli, Gustavo Pablo
Cafferata, Lázaro F. R.
author_sort Jeandupex, Rene
title Estabilidad térmica en endoperoxidos en solución: Ascaridol
title_short Estabilidad térmica en endoperoxidos en solución: Ascaridol
title_full Estabilidad térmica en endoperoxidos en solución: Ascaridol
title_fullStr Estabilidad térmica en endoperoxidos en solución: Ascaridol
title_full_unstemmed Estabilidad térmica en endoperoxidos en solución: Ascaridol
title_sort estabilidad térmica en endoperoxidos en solución: ascaridol
publishDate 2002
url http://sedici.unlp.edu.ar/handle/10915/96089
https://ri.conicet.gov.ar/11336/63652
work_keys_str_mv AT jeandupexrene estabilidadtermicaenendoperoxidosensolucionascaridol
AT romanelligustavopablo estabilidadtermicaenendoperoxidosensolucionascaridol
AT cafferatalazarofr estabilidadtermicaenendoperoxidosensolucionascaridol
bdutipo_str Repositorios
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