Identification of the Long Polar Fimbriae gene variants in Locus of Enterocyte Effacement-negative Shiga toxin-producing Escherichia coli strains isolated from humans and cattle in Argentina

The long polar fimbriae (Lpf) is one of few adhesive factors of Shiga toxin-producing Escherichia coli (STEC) and it is associated with colonization of the intestine. Studies have demonstrated the presence of lpf genes in several pathogenic E. coli strains, and classification of variants based on po...

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Detalles Bibliográficos
Autores principales: Galli, Lucía, Torres, Alfredo G., Rivas, Marta
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2010
Materias:
Ciencias Veterinarias
LEE-negative
Shiga toxin-producing Escherichia coli
lpf variant
Virulence profile;
Human strain;
Cattle strain
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/95998
https://ri.conicet.gov.ar/11336/79612
https://academic.oup.com/femsle/article/308/2/123/536763
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905465/
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-95998
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
LEE-negative
Shiga toxin-producing Escherichia coli
lpf variant
Virulence profile;
Human strain;
Cattle strain
spellingShingle Ciencias Veterinarias
LEE-negative
Shiga toxin-producing Escherichia coli
lpf variant
Virulence profile;
Human strain;
Cattle strain
Galli, Lucía
Torres, Alfredo G.
Rivas, Marta
Identification of the Long Polar Fimbriae gene variants in Locus of Enterocyte Effacement-negative Shiga toxin-producing Escherichia coli strains isolated from humans and cattle in Argentina
topic_facet Ciencias Veterinarias
LEE-negative
Shiga toxin-producing Escherichia coli
lpf variant
Virulence profile;
Human strain;
Cattle strain
description The long polar fimbriae (Lpf) is one of few adhesive factors of Shiga toxin-producing Escherichia coli (STEC) and it is associated with colonization of the intestine. Studies have demonstrated the presence of lpf genes in several pathogenic E. coli strains, and classification of variants based on polymorphisms in the lpfA1 and lpfA2 genes has been adopted. Using a collection of Argentinean locus of enterocyte effacement (LEE)-negative STEC strains, we determined that the different lpfA types were present in a wide variety of serotypes with no apparent association between the types of lpfA1 or lpfA2 genes and the severity of human disease. The lpfA2-1 was the most prevalent variant identified, which was present in 95.8% of the isolates, and lpfA1-3 and lpfA2-2, proposed as specific biomarkers of E. coli O157:H7, were not found in any of the serotypes studied. The prevalence of lpf genes in a large number of strains is useful to understand the genetic diversity of LEE-negative STEC and to define the association of some of these isolates carrying specific lpf-variants with disease.
format Articulo
Preprint
author Galli, Lucía
Torres, Alfredo G.
Rivas, Marta
author_facet Galli, Lucía
Torres, Alfredo G.
Rivas, Marta
author_sort Galli, Lucía
title Identification of the Long Polar Fimbriae gene variants in Locus of Enterocyte Effacement-negative Shiga toxin-producing Escherichia coli strains isolated from humans and cattle in Argentina
title_short Identification of the Long Polar Fimbriae gene variants in Locus of Enterocyte Effacement-negative Shiga toxin-producing Escherichia coli strains isolated from humans and cattle in Argentina
title_full Identification of the Long Polar Fimbriae gene variants in Locus of Enterocyte Effacement-negative Shiga toxin-producing Escherichia coli strains isolated from humans and cattle in Argentina
title_fullStr Identification of the Long Polar Fimbriae gene variants in Locus of Enterocyte Effacement-negative Shiga toxin-producing Escherichia coli strains isolated from humans and cattle in Argentina
title_full_unstemmed Identification of the Long Polar Fimbriae gene variants in Locus of Enterocyte Effacement-negative Shiga toxin-producing Escherichia coli strains isolated from humans and cattle in Argentina
title_sort identification of the long polar fimbriae gene variants in locus of enterocyte effacement-negative shiga toxin-producing escherichia coli strains isolated from humans and cattle in argentina
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/95998
https://ri.conicet.gov.ar/11336/79612
https://academic.oup.com/femsle/article/308/2/123/536763
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905465/
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