Mitochondrial-DNA phylogenetic information and the reconstruction of human population history : The south american case

Mitochondrial DNA (mtDNA) sequences are becoming increasingly important in the study of human population history. Here, we explore the differences in the amount of information of different mtDNA regions and their utility for the reconstruction of South American population history. We analyzed six da...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Postillone, María Bárbara, Pérez, Sergio Iván
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Naturales
Antropología
Bayesian methods
Molecular distances
Population dynamics
Substitution rates
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/95691
https://ri.conicet.gov.ar/11336/74187
https://www.jstor.org/stable/10.13110/humanbiology.89.3.05
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-95691
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Antropología
Bayesian methods
Molecular distances
Population dynamics
Substitution rates
spellingShingle Ciencias Naturales
Antropología
Bayesian methods
Molecular distances
Population dynamics
Substitution rates
Postillone, María Bárbara
Pérez, Sergio Iván
Mitochondrial-DNA phylogenetic information and the reconstruction of human population history : The south american case
topic_facet Ciencias Naturales
Antropología
Bayesian methods
Molecular distances
Population dynamics
Substitution rates
description Mitochondrial DNA (mtDNA) sequences are becoming increasingly important in the study of human population history. Here, we explore the differences in the amount of information of different mtDNA regions and their utility for the reconstruction of South American population history. We analyzed six data sets comprising 259 mtDNA sequences from South America: Complete mtDNA, Coding, Control, hypervariable region I (HVRI), Control plus cytochrome b (cytb), and cytb plus 12S plus 16S. The amount of information in each data set was estimated employing several site-by-site and haplotype-based statistics, distances among sequences, neighbor-joining trees, distances among the estimated trees, Bayesian skyline plots, and phylogenetic informativeness profiles. The different mtDNA data sets have different amounts of information to reconstruct demographic events and phylogenetic trees with confidence. Whereas HVRI is not suitable for phylogenetic reconstruction of ancient clades, this region, as well as the Control data set, displays information for the demographic reconstruction during the Holocene period, probably because of the high rate of mutation of these regions. As expected, the Complete mtDNA and Coding data sets, displaying slower rates of mutation, present suitable information to estimate the founding subhaplogroups that populated South America and for the reconstruction of ancient demographic events. Our results point out the importance of evaluating the utility of different DNA regions to respond to different questions and problems in the human population studies, mainly considering the time scale of the phenomenon and the informativeness of the molecular region in a particular geographical area.
format Articulo
Articulo
author Postillone, María Bárbara
Pérez, Sergio Iván
author_facet Postillone, María Bárbara
Pérez, Sergio Iván
author_sort Postillone, María Bárbara
title Mitochondrial-DNA phylogenetic information and the reconstruction of human population history : The south american case
title_short Mitochondrial-DNA phylogenetic information and the reconstruction of human population history : The south american case
title_full Mitochondrial-DNA phylogenetic information and the reconstruction of human population history : The south american case
title_fullStr Mitochondrial-DNA phylogenetic information and the reconstruction of human population history : The south american case
title_full_unstemmed Mitochondrial-DNA phylogenetic information and the reconstruction of human population history : The south american case
title_sort mitochondrial-dna phylogenetic information and the reconstruction of human population history : the south american case
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/95691
https://ri.conicet.gov.ar/11336/74187
https://www.jstor.org/stable/10.13110/humanbiology.89.3.05
work_keys_str_mv AT postillonemariabarbara mitochondrialdnaphylogeneticinformationandthereconstructionofhumanpopulationhistorythesouthamericancase
AT perezsergioivan mitochondrialdnaphylogeneticinformationandthereconstructionofhumanpopulationhistorythesouthamericancase
bdutipo_str Repositorios
_version_ 1764820492230852613

Ejemplares similares