Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent

A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt...

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Autores principales:	Escudero, Graciela Estela, Laino, Carlos Horacio, Martini, Nancy, Echeverría, Gustavo Alberto, Piro, Oscar Enrique, Williams, Patricia Ana María, Ferrer, Evelina Gloria
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2017
Materias:	Química Antidepressant Drug design Sertraline derivative Selective serotonin reuptake inhibitors Bioavailability
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/95118 https://ri.conicet.gov.ar/11336/66990 https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-95118
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Antidepressant Drug design Sertraline derivative Selective serotonin reuptake inhibitors Bioavailability
spellingShingle	Química Antidepressant Drug design Sertraline derivative Selective serotonin reuptake inhibitors Bioavailability Escudero, Graciela Estela Laino, Carlos Horacio Martini, Nancy Echeverría, Gustavo Alberto Piro, Oscar Enrique Williams, Patricia Ana María Ferrer, Evelina Gloria Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
topic_facet	Química Antidepressant Drug design Sertraline derivative Selective serotonin reuptake inhibitors Bioavailability
description	A novel compound for depression treatment and other psychiatric disorders has been obtained being capable of displaying the combined benefits of sertraline and an essential element such as zinc in order to get better antidepressant and negative side effects. Our working group has synthesized a salt formulation (SerH2 ) 2 +[ZnCl4 ] 2- (C34H36N2 Cl8 Zn, sertralonium tetrachlorozincate(II)). The crystal structure was determined by X-ray diffraction methods. It crystallizes in the monoclinic P21 space group with a=7.3869(2) Å, b=13.2888(4) Å, c=19.3541(6) Å, β=96.596(3)° Å, β=91.792(4)°, and Z=2 molecules per unit cell. Their antidepressant activity in the forced swimming test (FST) proved to be stronger than the one shown by the commercial drug sertraline hydrochloride per se. Furthermore, this compound suppressed the anorexigenic effect caused by the antidepressant and showed an improvement in the assimilation time during in vitro fluorescence studies with bovine serum albumin. The results of this work have led to a patent application which was filed (Nº 20150103320) in Argentine country.
format	Articulo Articulo
author	Escudero, Graciela Estela Laino, Carlos Horacio Martini, Nancy Echeverría, Gustavo Alberto Piro, Oscar Enrique Williams, Patricia Ana María Ferrer, Evelina Gloria
author_facet	Escudero, Graciela Estela Laino, Carlos Horacio Martini, Nancy Echeverría, Gustavo Alberto Piro, Oscar Enrique Williams, Patricia Ana María Ferrer, Evelina Gloria
author_sort	Escudero, Graciela Estela
title	Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_short	Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_full	Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_fullStr	Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_full_unstemmed	Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent
title_sort	zn(ii) based potential drug containing sertraline as a strong antidepressant agent
publishDate	2017
url	http://sedici.unlp.edu.ar/handle/10915/95118 https://ri.conicet.gov.ar/11336/66990 https://www.jscimedcentral.com/MedicinalChemistry/medicinalchemistry-3-1017.pdf
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bdutipo_str	Repositorios
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Zn(II) Based Potential Drug Containing Sertraline as a Strong Antidepressant Agent

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