Binary Local Fractal Dimension: a Precise Structure Parameter for 3D High Resolution Computed Tomography Images of the Human Spongiosa

We present the Binary Local Fractal Dimension (LFD) to analyze osteoporosis induced fracture risk with clinical 3D high resolution quantitative computed tomographic (HRCT) images of human vertebrae. We test if LFD parameters provide precise additional information besides bone mineral density (BMD) a...

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Autores principales: Thomsen, Felix, Peña, Jaime, Bastgen, Jan, Hoffmann, Beata, Frieling, Isolde, Glüer, Claus-C., Delrieux, Claudio
Formato: Objeto de conferencia
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Informáticas
Binary local fractal dimension
Hölder exponent
HRCT
Qualitative structure parameter
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/93439
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-93439
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Informáticas
Binary local fractal dimension
Hölder exponent
HRCT
Qualitative structure parameter
spellingShingle Ciencias Informáticas
Binary local fractal dimension
Hölder exponent
HRCT
Qualitative structure parameter
Thomsen, Felix
Peña, Jaime
Bastgen, Jan
Hoffmann, Beata
Frieling, Isolde
Glüer, Claus-C.
Delrieux, Claudio
Binary Local Fractal Dimension: a Precise Structure Parameter for 3D High Resolution Computed Tomography Images of the Human Spongiosa
topic_facet Ciencias Informáticas
Binary local fractal dimension
Hölder exponent
HRCT
Qualitative structure parameter
description We present the Binary Local Fractal Dimension (LFD) to analyze osteoporosis induced fracture risk with clinical 3D high resolution quantitative computed tomographic (HRCT) images of human vertebrae. We test if LFD parameters provide precise additional information besides bone mineral density (BMD) and standard descriptors of bone quality, for example bone surface ratio (BS/BV). We define a weighted LFD (wLFD) using the ¯R2 of the H¨older exponents. We compare the LFD with standard methods (distance transform, direct secant method and run-length method) on 5 vertebrae × 8 volumes of interest and 5 repeated scans. The wLFD contains the highest direct and BMD-independent precision (R2 = 0.985 and R2 = 0.949), followed by BS/BV (R2 = 0.977 and R2 = 0.920) including low correlation with BMD (wLFD: R2 = 0.704, BS/BV: R2 = 0.814). LFD improves the translation from reference μCT- to clinical HRCT-resolution. In conclusion, LFD provides a strong diagnostic tool to characterize bone quality to predict osteoporosis induced fracture risk.
format Objeto de conferencia
Objeto de conferencia
author Thomsen, Felix
Peña, Jaime
Bastgen, Jan
Hoffmann, Beata
Frieling, Isolde
Glüer, Claus-C.
Delrieux, Claudio
author_facet Thomsen, Felix
Peña, Jaime
Bastgen, Jan
Hoffmann, Beata
Frieling, Isolde
Glüer, Claus-C.
Delrieux, Claudio
author_sort Thomsen, Felix
title Binary Local Fractal Dimension: a Precise Structure Parameter for 3D High Resolution Computed Tomography Images of the Human Spongiosa
title_short Binary Local Fractal Dimension: a Precise Structure Parameter for 3D High Resolution Computed Tomography Images of the Human Spongiosa
title_full Binary Local Fractal Dimension: a Precise Structure Parameter for 3D High Resolution Computed Tomography Images of the Human Spongiosa
title_fullStr Binary Local Fractal Dimension: a Precise Structure Parameter for 3D High Resolution Computed Tomography Images of the Human Spongiosa
title_full_unstemmed Binary Local Fractal Dimension: a Precise Structure Parameter for 3D High Resolution Computed Tomography Images of the Human Spongiosa
title_sort binary local fractal dimension: a precise structure parameter for 3d high resolution computed tomography images of the human spongiosa
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/93439
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