White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies

A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on t...

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Detalles Bibliográficos
Autores principales:	Pagano, E. S., Spinedi, Eduardo Julio, Gagliardino, Juan José
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2016
Materias:	Ciencias Médicas Adipose tissue dysfunction Adipose tissue mass expansion Central/peripheral clocks Chronobiology Chronotherapeutic approach Clock genes Feeding time Glucose regulation Nutrients Obesity pathogenesis prevention Obesity treatment
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/87731
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Adipose tissue dysfunction Adipose tissue mass expansion Central/peripheral clocks Chronobiology Chronotherapeutic approach Clock genes Feeding time Glucose regulation Nutrients Obesity pathogenesis prevention Obesity treatment
spellingShingle	Ciencias Médicas Adipose tissue dysfunction Adipose tissue mass expansion Central/peripheral clocks Chronobiology Chronotherapeutic approach Clock genes Feeding time Glucose regulation Nutrients Obesity pathogenesis prevention Obesity treatment Pagano, E. S. Spinedi, Eduardo Julio Gagliardino, Juan José White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
topic_facet	Ciencias Médicas Adipose tissue dysfunction Adipose tissue mass expansion Central/peripheral clocks Chronobiology Chronotherapeutic approach Clock genes Feeding time Glucose regulation Nutrients Obesity pathogenesis prevention Obesity treatment
description	A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment.
format	Articulo Articulo
author	Pagano, E. S. Spinedi, Eduardo Julio Gagliardino, Juan José
author_facet	Pagano, E. S. Spinedi, Eduardo Julio Gagliardino, Juan José
author_sort	Pagano, E. S.
title	White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title_short	White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title_full	White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title_fullStr	White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title_full_unstemmed	White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies
title_sort	white adipose tissue and circadian rhythm dysfunctions in obesity : pathogenesis and available therapies
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/87731
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White adipose tissue and circadian rhythm dysfunctions in obesity : Pathogenesis and available therapies

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