Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses

Allatotropins (AT) are neuropeptides with pleotropic functions on a variety of insect tissues. They affect processes such as juvenile hormone biosynthesis, cardiac rhythm, oviduct and hindgut contractions, nutrient absorption and circadian cycle. The present work provides experimental evidence that...

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Autores principales: Hernández Martínez, Salvador, Sánchez Zavaleta, Minerva, Brito, Kevin, Herrera Ortiz, Antonia, Ons, Sheila, Noriega, Fernando G.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Exactas
mosquitoes
Allatotropin
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87655
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87655
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
mosquitoes
Allatotropin
spellingShingle Ciencias Exactas
mosquitoes
Allatotropin
Hernández Martínez, Salvador
Sánchez Zavaleta, Minerva
Brito, Kevin
Herrera Ortiz, Antonia
Ons, Sheila
Noriega, Fernando G.
Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses
topic_facet Ciencias Exactas
mosquitoes
Allatotropin
description Allatotropins (AT) are neuropeptides with pleotropic functions on a variety of insect tissues. They affect processes such as juvenile hormone biosynthesis, cardiac rhythm, oviduct and hindgut contractions, nutrient absorption and circadian cycle. The present work provides experimental evidence that AT elicits immune responses in two important mosquito disease vectors, <i>Anopheles albimanus</i> and <i>Aedes aegypti</i>. Hemocytes and an immune-competent mosquito cell line responded to AT by showing strong morphological changes and increasing bacterial phagocytic activity. Phenoloxidase activity in hemolymph was also increased in <i>Ae. aegypti</i> mosquitoes treated with AT but not in <i>An. albimanus</i>, suggesting differences in the AT-dependent immune activation in the two species. In addition, two important insect immune markers, nitric oxide levels and expression of antimicrobial peptide genes, were increased in <i>An. albimanus</i> guts after AT treatment. AT conjugated to quantum dot nanocrystals (QDots) specifically labeled hemocytes <i>in vivo</i> in both mosquito species, implying molecular interactions between AT and hemocytes. The results of our studies suggest a new role for AT in the modulation of the immune response in mosquitoes.
format Articulo
Articulo
author Hernández Martínez, Salvador
Sánchez Zavaleta, Minerva
Brito, Kevin
Herrera Ortiz, Antonia
Ons, Sheila
Noriega, Fernando G.
author_facet Hernández Martínez, Salvador
Sánchez Zavaleta, Minerva
Brito, Kevin
Herrera Ortiz, Antonia
Ons, Sheila
Noriega, Fernando G.
author_sort Hernández Martínez, Salvador
title Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses
title_short Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses
title_full Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses
title_fullStr Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses
title_full_unstemmed Allatotropin: A pleiotropic neuropeptide that elicits mosquito immune responses
title_sort allatotropin: a pleiotropic neuropeptide that elicits mosquito immune responses
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/87655
work_keys_str_mv AT hernandezmartinezsalvador allatotropinapleiotropicneuropeptidethatelicitsmosquitoimmuneresponses
AT sanchezzavaletaminerva allatotropinapleiotropicneuropeptidethatelicitsmosquitoimmuneresponses
AT britokevin allatotropinapleiotropicneuropeptidethatelicitsmosquitoimmuneresponses
AT herreraortizantonia allatotropinapleiotropicneuropeptidethatelicitsmosquitoimmuneresponses
AT onssheila allatotropinapleiotropicneuropeptidethatelicitsmosquitoimmuneresponses
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bdutipo_str Repositorios
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