Impact of RyR2 potentiation on myocardial function

This perspective attempts to shed light on an old and not yet solved controversy in cardiac physiology, i.e., the impact of increasing ryanodine receptor (RyR)2 open probability on myocardial function. Based on an already proven myocyte model, it was shown that increasing RyR2 open probability resul...

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Autores principales: Lascano, Elena Catalina, Negroni, Jorge Antonio, Vila Petroff, Martín Gerardo, Mattiazzi, Alicia Ramona
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Médicas
Contractility
Heart
Open probability
Ryanodine receptor
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87547
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87547
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Contractility
Heart
Open probability
Ryanodine receptor
spellingShingle Ciencias Médicas
Contractility
Heart
Open probability
Ryanodine receptor
Lascano, Elena Catalina
Negroni, Jorge Antonio
Vila Petroff, Martín Gerardo
Mattiazzi, Alicia Ramona
Impact of RyR2 potentiation on myocardial function
topic_facet Ciencias Médicas
Contractility
Heart
Open probability
Ryanodine receptor
description This perspective attempts to shed light on an old and not yet solved controversy in cardiac physiology, i.e., the impact of increasing ryanodine receptor (RyR)2 open probability on myocardial function. Based on an already proven myocyte model, it was shown that increasing RyR2 open probability results in a purely short-lived increase in Ca2+ transient amplitude, and, therefore, it does not increase cardiac contractility. However, potentiation of RyR2 activity permanently enhances fractional Ca2+ release, shifting the intracellular Ca2+ transient versus sarcoplasmic reticulum (SR) Ca2+ content curve to a new state of higher efficiency. This would allow the heart to maintain a given contractility despite a decrease in SR Ca2+ content, to enhance contractility if SR Ca2+ content is simultaneously preserved or to successfully counteract the effects of a negative inotropic intervention. New & Noteworthy Increasing ryanodine receptor (RyR)2 open probability does not increase cardiac contractility. However, RyR2 potentiation shifts the intracellular Ca2+ transient-sarcoplasmic reticulum (SR) Ca2+ content relationship toward an enhanced efficiency state, which may contribute to a positive inotropic effect, preserve contractility despite decreased SR Ca2+ content, or successfully counteract the effects of a negative inotropic action
format Articulo
Articulo
author Lascano, Elena Catalina
Negroni, Jorge Antonio
Vila Petroff, Martín Gerardo
Mattiazzi, Alicia Ramona
author_facet Lascano, Elena Catalina
Negroni, Jorge Antonio
Vila Petroff, Martín Gerardo
Mattiazzi, Alicia Ramona
author_sort Lascano, Elena Catalina
title Impact of RyR2 potentiation on myocardial function
title_short Impact of RyR2 potentiation on myocardial function
title_full Impact of RyR2 potentiation on myocardial function
title_fullStr Impact of RyR2 potentiation on myocardial function
title_full_unstemmed Impact of RyR2 potentiation on myocardial function
title_sort impact of ryr2 potentiation on myocardial function
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/87547
work_keys_str_mv AT lascanoelenacatalina impactofryr2potentiationonmyocardialfunction
AT negronijorgeantonio impactofryr2potentiationonmyocardialfunction
AT vilapetroffmartingerardo impactofryr2potentiationonmyocardialfunction
AT mattiazzialiciaramona impactofryr2potentiationonmyocardialfunction
bdutipo_str Repositorios
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