Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner

Voltage-gated Ca2+ (CaV) channels couple membrane depolarization to Ca2+ influx, triggering a range ofCa2+-dependent cellular processes. CaV channels are, therefore, crucial in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many ne...

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Detalles Bibliográficos
Autores principales: Mustafá, Emilio Román, López Soto, Eduardo Javier, Martínez Damonte, Valentina, Rodríguez, Silvia Susana, Lipscombe, Diane, Raingo, Jesica
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Biología
CaVβ
GPCR
Voltage-gated calcium (Ca2+) channels
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87538
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87538
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
CaVβ
GPCR
Voltage-gated calcium (Ca2+) channels
spellingShingle Biología
CaVβ
GPCR
Voltage-gated calcium (Ca2+) channels
Mustafá, Emilio Román
López Soto, Eduardo Javier
Martínez Damonte, Valentina
Rodríguez, Silvia Susana
Lipscombe, Diane
Raingo, Jesica
Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner
topic_facet Biología
CaVβ
GPCR
Voltage-gated calcium (Ca2+) channels
description Voltage-gated Ca2+ (CaV) channels couple membrane depolarization to Ca2+ influx, triggering a range ofCa2+-dependent cellular processes. CaV channels are, therefore, crucial in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many neurotransmitters and drugs that act through G protein coupled receptors (GPCRs), modulate neuronal activity by altering the expression, trafficking, or function of CaV channels. GPCRdependent mechanisms that downregulate CaV channel expression levels are observed in many neurons but are, by comparison, less studied. Herewe showthat the growth hormone secretagogue receptor type 1a (GHSR), a GPCR, can inhibit the forwarding trafficking of severalCaV subtypes, even in the absence of agonist. This constitutive form ofGPCRinhibition of CaV channels depends on the presence of a CaVβ subunit. CaVβ subunits displace CaVα1 subunits from the endoplasmic reticulum. The actions of GHSR on CaV channels trafficking suggest a role for this signaling pathway in brain areas that control food intake, reward, and learning and memory.
format Articulo
Articulo
author Mustafá, Emilio Román
López Soto, Eduardo Javier
Martínez Damonte, Valentina
Rodríguez, Silvia Susana
Lipscombe, Diane
Raingo, Jesica
author_facet Mustafá, Emilio Román
López Soto, Eduardo Javier
Martínez Damonte, Valentina
Rodríguez, Silvia Susana
Lipscombe, Diane
Raingo, Jesica
author_sort Mustafá, Emilio Román
title Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner
title_short Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner
title_full Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner
title_fullStr Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner
title_full_unstemmed Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner
title_sort constitutive activity of the ghrelin receptor reduces surface expression of voltage-gated ca2+ channels in a cavβ-dependent manner
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/87538
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AT lopezsotoeduardojavier constitutiveactivityoftheghrelinreceptorreducessurfaceexpressionofvoltagegatedca2channelsinacavbdependentmanner
AT martinezdamontevalentina constitutiveactivityoftheghrelinreceptorreducessurfaceexpressionofvoltagegatedca2channelsinacavbdependentmanner
AT rodriguezsilviasusana constitutiveactivityoftheghrelinreceptorreducessurfaceexpressionofvoltagegatedca2channelsinacavbdependentmanner
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bdutipo_str Repositorios
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