Changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex

Aging leads to adverse outcomes after traumatic brain injury. The mechanisms underlying these defects, however, are not yet clear. In this study, we found that astrocytes in the aged post-traumatic cerebral cortex develop a significantly reduced proliferative response, resulting in reduced astrocyte...

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Detalles Bibliográficos
Autores principales: Heimann, Gábor, Canhos, Luisa L., Frik, Jesica, Jäger, Gabriele, Lepko, Tjasa, Ninkovic, Jovica, Götz, Magdalena, Sirko, Swetlana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Exactas
Aging
Brain injury
Cell division
GFAP
Glia
Reactive gliosis
Self-renewal
Shh
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87440
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata

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