Changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex

Aging leads to adverse outcomes after traumatic brain injury. The mechanisms underlying these defects, however, are not yet clear. In this study, we found that astrocytes in the aged post-traumatic cerebral cortex develop a significantly reduced proliferative response, resulting in reduced astrocyte...

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Autores principales: Heimann, Gábor, Canhos, Luisa L., Frik, Jesica, Jäger, Gabriele, Lepko, Tjasa, Ninkovic, Jovica, Götz, Magdalena, Sirko, Swetlana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Exactas
Aging
Brain injury
Cell division
GFAP
Glia
Reactive gliosis
Self-renewal
Shh
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87440
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87440
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Aging
Brain injury
Cell division
GFAP
Glia
Reactive gliosis
Self-renewal
Shh
spellingShingle Ciencias Exactas
Aging
Brain injury
Cell division
GFAP
Glia
Reactive gliosis
Self-renewal
Shh
Heimann, Gábor
Canhos, Luisa L.
Frik, Jesica
Jäger, Gabriele
Lepko, Tjasa
Ninkovic, Jovica
Götz, Magdalena
Sirko, Swetlana
Changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex
topic_facet Ciencias Exactas
Aging
Brain injury
Cell division
GFAP
Glia
Reactive gliosis
Self-renewal
Shh
description Aging leads to adverse outcomes after traumatic brain injury. The mechanisms underlying these defects, however, are not yet clear. In this study, we found that astrocytes in the aged post-traumatic cerebral cortex develop a significantly reduced proliferative response, resulting in reduced astrocyte numbers in the penumbra. Moreover, experiments of reactive astrocytes in vitro reveal that their diminished proliferation is due to an age-related switch in the division mode with reduced cell-cycle re-entry rather than changes in cell-cycle length. Notably, reactive astrocytes in vivo and in vitro become refractory to stimuli increasing their proliferation during aging, such as Sonic hedgehog signaling. These data demonstrate for the first time that age-dependent, most likely intrinsic changes in the proliferative program of reactive astrocytes result in their severely hampered proliferative response to traumatic injury thereby affecting astrocyte homeostasis.
format Articulo
Articulo
author Heimann, Gábor
Canhos, Luisa L.
Frik, Jesica
Jäger, Gabriele
Lepko, Tjasa
Ninkovic, Jovica
Götz, Magdalena
Sirko, Swetlana
author_facet Heimann, Gábor
Canhos, Luisa L.
Frik, Jesica
Jäger, Gabriele
Lepko, Tjasa
Ninkovic, Jovica
Götz, Magdalena
Sirko, Swetlana
author_sort Heimann, Gábor
title Changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex
title_short Changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex
title_full Changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex
title_fullStr Changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex
title_full_unstemmed Changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex
title_sort changes in the proliferative program limit astrocyte homeostasis in the aged post-traumatic murine cerebral cortex
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/87440
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bdutipo_str Repositorios
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