The role of cytokines in the fibrotic responses in Crohn's disease

Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with typical transmural lesions. Complications, inc...

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Detalles Bibliográficos
Autores principales:	Curciarello, Renata, Docena, Guillermo Horacio, MacDonald, Thomas T.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2017
Materias:	Ciencias Exactas Chronic inflammation Crohn's disease Cytokines Extracellular matrix Fibrosis Fibrostenosis Strictures
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/87426
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-87426
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Chronic inflammation Crohn's disease Cytokines Extracellular matrix Fibrosis Fibrostenosis Strictures
spellingShingle	Ciencias Exactas Chronic inflammation Crohn's disease Cytokines Extracellular matrix Fibrosis Fibrostenosis Strictures Curciarello, Renata Docena, Guillermo Horacio MacDonald, Thomas T. The role of cytokines in the fibrotic responses in Crohn's disease
topic_facet	Ciencias Exactas Chronic inflammation Crohn's disease Cytokines Extracellular matrix Fibrosis Fibrostenosis Strictures
description	Crohn's disease is an idiopathic disorder of the gut thought to be caused by a combination of environmental and genetic factors in susceptible individuals. It is characterized by chronic transmural inflammation of the terminal ileum and colon, with typical transmural lesions. Complications, including fibrosis, mean that between 40 and 70% of patients require surgery in the first 10 years after diagnosis. Presently, there is no evidence that the current therapies which dampen inflammation modulate or reverse intestinal fibrosis. In this review, we focus on cytokines that may lead to fibrosis and stenosis and the contribution of experimental models for understanding and treatment of gut fibrosis.
format	Articulo Articulo
author	Curciarello, Renata Docena, Guillermo Horacio MacDonald, Thomas T.
author_facet	Curciarello, Renata Docena, Guillermo Horacio MacDonald, Thomas T.
author_sort	Curciarello, Renata
title	The role of cytokines in the fibrotic responses in Crohn's disease
title_short	The role of cytokines in the fibrotic responses in Crohn's disease
title_full	The role of cytokines in the fibrotic responses in Crohn's disease
title_fullStr	The role of cytokines in the fibrotic responses in Crohn's disease
title_full_unstemmed	The role of cytokines in the fibrotic responses in Crohn's disease
title_sort	role of cytokines in the fibrotic responses in crohn's disease
publishDate	2017
url	http://sedici.unlp.edu.ar/handle/10915/87426
work_keys_str_mv	AT curciarellorenata theroleofcytokinesinthefibroticresponsesincrohnsdisease AT docenaguillermohoracio theroleofcytokinesinthefibroticresponsesincrohnsdisease AT macdonaldthomast theroleofcytokinesinthefibroticresponsesincrohnsdisease AT curciarellorenata roleofcytokinesinthefibroticresponsesincrohnsdisease AT docenaguillermohoracio roleofcytokinesinthefibroticresponsesincrohnsdisease AT macdonaldthomast roleofcytokinesinthefibroticresponsesincrohnsdisease
bdutipo_str	Repositorios
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The role of cytokines in the fibrotic responses in Crohn's disease

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