Heat stress induces ferroptosis-like cell death in plants
In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process c...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/87410 |
| Aporte de: |
| id |
I19-R120-10915-87410 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Biología Botánica Cell death process Plants Iron-dependent cell |
| spellingShingle |
Biología Botánica Cell death process Plants Iron-dependent cell Distéfano, Ayelén Mariana Martin, María Victoria Córdoba, Juan Pablo Bellido, Andrés Martín D’Ippólito, Sebastián Colman, Silvana Lorena Soto, Débora Roldán, Juan Alfredo Bartoli, Carlos Guillermo Zabaleta, Eduardo Julián Fiol, Diego Fernando Stockwell, Brent R. Dixon, Scott J. Pagnussat, Gabriela Carolina Heat stress induces ferroptosis-like cell death in plants |
| topic_facet |
Biología Botánica Cell death process Plants Iron-dependent cell |
| description |
In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)-induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient. |
| format |
Articulo Articulo |
| author |
Distéfano, Ayelén Mariana Martin, María Victoria Córdoba, Juan Pablo Bellido, Andrés Martín D’Ippólito, Sebastián Colman, Silvana Lorena Soto, Débora Roldán, Juan Alfredo Bartoli, Carlos Guillermo Zabaleta, Eduardo Julián Fiol, Diego Fernando Stockwell, Brent R. Dixon, Scott J. Pagnussat, Gabriela Carolina |
| author_facet |
Distéfano, Ayelén Mariana Martin, María Victoria Córdoba, Juan Pablo Bellido, Andrés Martín D’Ippólito, Sebastián Colman, Silvana Lorena Soto, Débora Roldán, Juan Alfredo Bartoli, Carlos Guillermo Zabaleta, Eduardo Julián Fiol, Diego Fernando Stockwell, Brent R. Dixon, Scott J. Pagnussat, Gabriela Carolina |
| author_sort |
Distéfano, Ayelén Mariana |
| title |
Heat stress induces ferroptosis-like cell death in plants |
| title_short |
Heat stress induces ferroptosis-like cell death in plants |
| title_full |
Heat stress induces ferroptosis-like cell death in plants |
| title_fullStr |
Heat stress induces ferroptosis-like cell death in plants |
| title_full_unstemmed |
Heat stress induces ferroptosis-like cell death in plants |
| title_sort |
heat stress induces ferroptosis-like cell death in plants |
| publishDate |
2017 |
| url |
http://sedici.unlp.edu.ar/handle/10915/87410 |
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Repositorios |
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1764820490006822915 |