Detection and Magnetic Source Imaging of Fast Oscillations (40–160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients

We present a framework to detect fast oscillations (FOs) in magnetoencephalography (MEG) and to perform magnetic source imaging (MSI) to determine the location and extent of their generators in the cortex. FOs can be of physiologic origin associated to sensory processing and memory consolidation. In...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ellenrieder, Nicolás von, Pellegrino, Giovanni, Hedrich, Tanguy, Gotman, Jean, Lina, Jean Marc, Grova, Christophe, Kobayashi, Eliane
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ingeniería
Ciencias Médicas
Automatic detection
Epilepsy
High frequency activity
Human
Source localization
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87021
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87021
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ingeniería
Ciencias Médicas
Automatic detection
Epilepsy
High frequency activity
Human
Source localization
spellingShingle Ingeniería
Ciencias Médicas
Automatic detection
Epilepsy
High frequency activity
Human
Source localization
Ellenrieder, Nicolás von
Pellegrino, Giovanni
Hedrich, Tanguy
Gotman, Jean
Lina, Jean Marc
Grova, Christophe
Kobayashi, Eliane
Detection and Magnetic Source Imaging of Fast Oscillations (40–160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients
topic_facet Ingeniería
Ciencias Médicas
Automatic detection
Epilepsy
High frequency activity
Human
Source localization
description We present a framework to detect fast oscillations (FOs) in magnetoencephalography (MEG) and to perform magnetic source imaging (MSI) to determine the location and extent of their generators in the cortex. FOs can be of physiologic origin associated to sensory processing and memory consolidation. In epilepsy, FOs are of pathologic origin and biomarkers of the epileptogenic zone. Seventeen patients with focal epilepsy previously confirmed with identified FOs in scalp electroencephalography (EEG) were evaluated. To handle data deriving from large number of sensors (275 axial gradiometers) we used an automatic detector with high sensitivity. False positives were discarded by two human experts. MSI of the FOs was performed with the wavelet based maximum entropy on the mean method. We found FOs in 11/17 patients, in only one patient the channel with highest FO rate was not concordant with the epileptogenic region and might correspond to physiologic oscillations. MEG FOs rates were very low: 0.02–4.55 per minute. Compared to scalp EEG, detection sensitivity was lower, but the specificity higher in MEG. MSI of FOs showed concordance or partial concordance with proven generators of seizures and epileptiform activity in 10/11 patients. We have validated the proposed framework for the non-invasive study of FOs with MEG. The excellent overall concordance with other clinical gold standard evaluation tools indicates that MEG FOs can provide relevant information to guide implantation for intracranial EEG pre-surgical evaluation and for surgical treatment, and demonstrates the important added value of choosing appropriate FOs detection and source localization methods.
format Articulo
Articulo
author Ellenrieder, Nicolás von
Pellegrino, Giovanni
Hedrich, Tanguy
Gotman, Jean
Lina, Jean Marc
Grova, Christophe
Kobayashi, Eliane
author_facet Ellenrieder, Nicolás von
Pellegrino, Giovanni
Hedrich, Tanguy
Gotman, Jean
Lina, Jean Marc
Grova, Christophe
Kobayashi, Eliane
author_sort Ellenrieder, Nicolás von
title Detection and Magnetic Source Imaging of Fast Oscillations (40–160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients
title_short Detection and Magnetic Source Imaging of Fast Oscillations (40–160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients
title_full Detection and Magnetic Source Imaging of Fast Oscillations (40–160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients
title_fullStr Detection and Magnetic Source Imaging of Fast Oscillations (40–160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients
title_full_unstemmed Detection and Magnetic Source Imaging of Fast Oscillations (40–160 Hz) Recorded with Magnetoencephalography in Focal Epilepsy Patients
title_sort detection and magnetic source imaging of fast oscillations (40–160 hz) recorded with magnetoencephalography in focal epilepsy patients
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/87021
work_keys_str_mv AT ellenriedernicolasvon detectionandmagneticsourceimagingoffastoscillations40160hzrecordedwithmagnetoencephalographyinfocalepilepsypatients
AT pellegrinogiovanni detectionandmagneticsourceimagingoffastoscillations40160hzrecordedwithmagnetoencephalographyinfocalepilepsypatients
AT hedrichtanguy detectionandmagneticsourceimagingoffastoscillations40160hzrecordedwithmagnetoencephalographyinfocalepilepsypatients
AT gotmanjean detectionandmagneticsourceimagingoffastoscillations40160hzrecordedwithmagnetoencephalographyinfocalepilepsypatients
AT linajeanmarc detectionandmagneticsourceimagingoffastoscillations40160hzrecordedwithmagnetoencephalographyinfocalepilepsypatients
AT grovachristophe detectionandmagneticsourceimagingoffastoscillations40160hzrecordedwithmagnetoencephalographyinfocalepilepsypatients
AT kobayashieliane detectionandmagneticsourceimagingoffastoscillations40160hzrecordedwithmagnetoencephalographyinfocalepilepsypatients
bdutipo_str Repositorios
_version_ 1764820489561178114

Ejemplares similares