Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease
Impairments of action language have been documented in early stage Parkinson's disease (EPD). The action-sentence compatibility effect (ACE) paradigm has revealed that EPD involves deficits to integrate action-verb processing and ongoing motor actions. Recent studies suggest that an abolished A...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/86715 |
| Aporte de: |
| id |
I19-R120-10915-86715 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Exactas Ciencias Médicas Parkinson’s disease |
| spellingShingle |
Ciencias Exactas Ciencias Médicas Parkinson’s disease Melloni, Margherita Sedeño, Lucas Hesse, Eugenia García Cordero, Indira Mikulan, Ezequiel Plastino, Ángel Luis Marcotti, Aida López, José David Bustamante, Catalina Lopera, Francisco Pineda, David García, Adolfo M. Manes, Facundo Trujillo, Natalia Ibáñez, Agustín Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease |
| topic_facet |
Ciencias Exactas Ciencias Médicas Parkinson’s disease |
| description |
Impairments of action language have been documented in early stage Parkinson's disease (EPD). The action-sentence compatibility effect (ACE) paradigm has revealed that EPD involves deficits to integrate action-verb processing and ongoing motor actions. Recent studies suggest that an abolished ACE in EPD reflects a cortico-subcortical disruption, and recent neurocognitive models highlight the role of the basal ganglia (BG) in motor-language coupling. Building on such breakthroughs, we report the first exploration of convergent cortical and subcortical signatures of ACE in EPD patients and matched controls. Specifically, we combined cortical recordings of the motor potential, functional connectivity measures, and structural analysis of the BG through voxel-based morphometry. Relative to controls, EPD patients exhibited an impaired ACE, a reduced motor potential, and aberrant frontotemporal connectivity. Furthermore, motor potential abnormalities during the ACE task were predicted by overall BG volume and atrophy. These results corroborate that motor-language coupling is mainly subserved by a cortico-subcortical network including the BG as a key hub. They also evince that action-verb processing may constitute a neurocognitive marker of EPD. Our findings suggest that research on the relationship between language and motor domains is crucial to develop models of motor cognition as well as diagnostic and intervention strategies. |
| format |
Articulo Articulo |
| author |
Melloni, Margherita Sedeño, Lucas Hesse, Eugenia García Cordero, Indira Mikulan, Ezequiel Plastino, Ángel Luis Marcotti, Aida López, José David Bustamante, Catalina Lopera, Francisco Pineda, David García, Adolfo M. Manes, Facundo Trujillo, Natalia Ibáñez, Agustín |
| author_facet |
Melloni, Margherita Sedeño, Lucas Hesse, Eugenia García Cordero, Indira Mikulan, Ezequiel Plastino, Ángel Luis Marcotti, Aida López, José David Bustamante, Catalina Lopera, Francisco Pineda, David García, Adolfo M. Manes, Facundo Trujillo, Natalia Ibáñez, Agustín |
| author_sort |
Melloni, Margherita |
| title |
Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease |
| title_short |
Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease |
| title_full |
Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease |
| title_fullStr |
Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease |
| title_full_unstemmed |
Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease |
| title_sort |
cortical dynamics and subcortical signatures of motor-language coupling in parkinson's disease |
| publishDate |
2015 |
| url |
http://sedici.unlp.edu.ar/handle/10915/86715 |
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