Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino) ethyl methacrylate (DPA) and different amounts of cross-linker agent, eth...

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Detalles Bibliográficos
Autores principales: Faccia, Paula Andrea, Pardini, Francisco Martín, Amalvy, Javier Ignacio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Química
2-(diisoproylamino)ethyl methacrylate
2-hydroxyethyl methacrylate
Drug delivery systems
pH-sensitive hydrogels
Smart polymers
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86640
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86640
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
2-(diisoproylamino)ethyl methacrylate
2-hydroxyethyl methacrylate
Drug delivery systems
pH-sensitive hydrogels
Smart polymers
spellingShingle Química
2-(diisoproylamino)ethyl methacrylate
2-hydroxyethyl methacrylate
Drug delivery systems
pH-sensitive hydrogels
Smart polymers
Faccia, Paula Andrea
Pardini, Francisco Martín
Amalvy, Javier Ignacio
Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
topic_facet Química
2-(diisoproylamino)ethyl methacrylate
2-hydroxyethyl methacrylate
Drug delivery systems
pH-sensitive hydrogels
Smart polymers
description Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino) ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH-sensitive drug delivery systems for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by Fourier Transform Infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.
format Articulo
Articulo
author Faccia, Paula Andrea
Pardini, Francisco Martín
Amalvy, Javier Ignacio
author_facet Faccia, Paula Andrea
Pardini, Francisco Martín
Amalvy, Javier Ignacio
author_sort Faccia, Paula Andrea
title Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title_short Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title_full Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title_fullStr Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title_full_unstemmed Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
title_sort evaluation of ph-sensitive poly(2-hydroxyethyl methacrylate-co-2 (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/86640
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AT amalvyjavierignacio evaluationofphsensitivepoly2hydroxyethylmethacrylateco2diisopropylaminoethylmethacrylatecopolymersasdrugdeliverysystemsforpotentialapplicationsinophthalmictherapiesoculardeliveryofdrugs
bdutipo_str Repositorios
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