Polymorphic variants in oxidative stress genes and acute toxicity in breast cancer patients receiving radiotherapy

Purpose. Reactive oxygen species (ROS) are generated as an indirect product of radiation therapy (RT). Genetic variation in genes related to ROS metabolism may influence the level of RT-induced adverse effects. We evaluated the potential association of single nucleotide polymorphism (SNP)-related re...

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Autores principales: Córdoba, Elisa Eugenia, Abba, Martín Carlos, Lacunza, Ezequiel, Fernández, Eduardo, Güerci, Alba Mabel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Exactas
Ciencias Médicas
Acute toxicity
Breast neoplasm
Oxidative stress
Radiation tolerance
Radiotherapy
Single nucleotide polymorphism
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86630
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86630
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Ciencias Médicas
Acute toxicity
Breast neoplasm
Oxidative stress
Radiation tolerance
Radiotherapy
Single nucleotide polymorphism
spellingShingle Ciencias Exactas
Ciencias Médicas
Acute toxicity
Breast neoplasm
Oxidative stress
Radiation tolerance
Radiotherapy
Single nucleotide polymorphism
Córdoba, Elisa Eugenia
Abba, Martín Carlos
Lacunza, Ezequiel
Fernández, Eduardo
Güerci, Alba Mabel
Polymorphic variants in oxidative stress genes and acute toxicity in breast cancer patients receiving radiotherapy
topic_facet Ciencias Exactas
Ciencias Médicas
Acute toxicity
Breast neoplasm
Oxidative stress
Radiation tolerance
Radiotherapy
Single nucleotide polymorphism
description Purpose. Reactive oxygen species (ROS) are generated as an indirect product of radiation therapy (RT). Genetic variation in genes related to ROS metabolism may influence the level of RT-induced adverse effects. We evaluated the potential association of single nucleotide polymorphism (SNP)-related response to radiotherapy injury in breast cancer patients undergoing RT. Materials and Methods. Eighty patients receiving conventional RT were included. Acute effects were evaluated according to the Radiation Therapy Oncology Group (RTOG) scores. DNA was extracted from blood and buccal swab samples. SNPs were genotyped for GSTP1, GSTA1, SOD2, and NOS3 genes by polymerase chain reaction-based restriction fragment length polymorphism. Univariate analysis (odds ratios [ORs] and 95% confidence interval [CI]) and principal component analysis were used for correlation of SNPs and factors related to risk of developing ≥ grade 2 acute effects. Results. Sixty-five patients (81.2%) showed side effects, 32 (40%) presented moderate to severe acute skin toxicity, and 33 (41.2%) manifested minimal acute skin reactions by the end of treatment. In both univariate and multivariate analyses, nominally significant associations were found among body mass index (OR, 3.14; 95% CI, 8.5338 to 1.1274; p=0.022), breast size (OR, 5.11; 95% CI, 17.04 to 1.54; p=0.004), and grade ≥ 2 acute radiation skin toxicity. A significant association was also observed between NOS3 G894T polymorphism (OR, 9.8; 95% CI, 211.6 to 0.45; p=0.041) and grade ≥ 2 acute radiation skin toxicity in patients with neo-adjuvant chemotherapy treatment. Conclusion. The analysis of the factors involved in individual radiosensitivity contributed to the understanding of the mechanisms underlying this trait.
format Articulo
Articulo
author Córdoba, Elisa Eugenia
Abba, Martín Carlos
Lacunza, Ezequiel
Fernández, Eduardo
Güerci, Alba Mabel
author_facet Córdoba, Elisa Eugenia
Abba, Martín Carlos
Lacunza, Ezequiel
Fernández, Eduardo
Güerci, Alba Mabel
author_sort Córdoba, Elisa Eugenia
title Polymorphic variants in oxidative stress genes and acute toxicity in breast cancer patients receiving radiotherapy
title_short Polymorphic variants in oxidative stress genes and acute toxicity in breast cancer patients receiving radiotherapy
title_full Polymorphic variants in oxidative stress genes and acute toxicity in breast cancer patients receiving radiotherapy
title_fullStr Polymorphic variants in oxidative stress genes and acute toxicity in breast cancer patients receiving radiotherapy
title_full_unstemmed Polymorphic variants in oxidative stress genes and acute toxicity in breast cancer patients receiving radiotherapy
title_sort polymorphic variants in oxidative stress genes and acute toxicity in breast cancer patients receiving radiotherapy
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/86630
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bdutipo_str Repositorios
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