Quantification of residual enrofloxacin and ciprofloxacin in feathers of broiler chickens by high-performance liquid chromatography-fluorescence after oral administration of the drugs

Enrofloxacin (ENR) and ciprofloxacin (CIP) are drugs used in poultry feeding. In general, feathers that are incorporated in the food chain as a protein source for animal feed, have residues of these drugs. In order to study the pharmacokinetic of ENR/CIP residues in feathers of broiler chickens, to...

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Detalles Bibliográficos
Autores principales: Haag, Griselda, Marín, Gustavo Horacio, Errecalde, Jorge Oscar
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Química
Enrofloxacin
quantification
quinolones
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86293
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86293
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Enrofloxacin
quantification
quinolones
spellingShingle Química
Enrofloxacin
quantification
quinolones
Haag, Griselda
Marín, Gustavo Horacio
Errecalde, Jorge Oscar
Quantification of residual enrofloxacin and ciprofloxacin in feathers of broiler chickens by high-performance liquid chromatography-fluorescence after oral administration of the drugs
topic_facet Química
Enrofloxacin
quantification
quinolones
description Enrofloxacin (ENR) and ciprofloxacin (CIP) are drugs used in poultry feeding. In general, feathers that are incorporated in the food chain as a protein source for animal feed, have residues of these drugs. In order to study the pharmacokinetic of ENR/CIP residues in feathers of broiler chickens, to calculate the waiting times for these drugs, before human consumption, we developed the present research. Feathers of broiler chickens were enriched with ENR/CIP. After adding acetone, the mix was agitated and centrifuged and supernatant evaporated under nitrogen. The dry residue was suspended in a tetrahydrofuran solution and the supernatant was injected into the chromatographic system for analysis. Animals showed high levels of ENR/CIP in their feathers after administration of 10 mg/kg enrofloxacin dissolved in drinking water for 5 days. Both compounds were detected in feathers during 9 days. The analytical method developed in this paper to determine ENR and CIP in feathers of broiler chicken showed good linearity, selectivity, accuracy and precision in the analysis conditions. This technique could have important applications in the studies on residues of ENR/CIP in feathers, since the effect of this component in animal diets has not been considered yet.
format Articulo
Articulo
author Haag, Griselda
Marín, Gustavo Horacio
Errecalde, Jorge Oscar
author_facet Haag, Griselda
Marín, Gustavo Horacio
Errecalde, Jorge Oscar
author_sort Haag, Griselda
title Quantification of residual enrofloxacin and ciprofloxacin in feathers of broiler chickens by high-performance liquid chromatography-fluorescence after oral administration of the drugs
title_short Quantification of residual enrofloxacin and ciprofloxacin in feathers of broiler chickens by high-performance liquid chromatography-fluorescence after oral administration of the drugs
title_full Quantification of residual enrofloxacin and ciprofloxacin in feathers of broiler chickens by high-performance liquid chromatography-fluorescence after oral administration of the drugs
title_fullStr Quantification of residual enrofloxacin and ciprofloxacin in feathers of broiler chickens by high-performance liquid chromatography-fluorescence after oral administration of the drugs
title_full_unstemmed Quantification of residual enrofloxacin and ciprofloxacin in feathers of broiler chickens by high-performance liquid chromatography-fluorescence after oral administration of the drugs
title_sort quantification of residual enrofloxacin and ciprofloxacin in feathers of broiler chickens by high-performance liquid chromatography-fluorescence after oral administration of the drugs
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/86293
work_keys_str_mv AT haaggriselda quantificationofresidualenrofloxacinandciprofloxacininfeathersofbroilerchickensbyhighperformanceliquidchromatographyfluorescenceafteroraladministrationofthedrugs
AT maringustavohoracio quantificationofresidualenrofloxacinandciprofloxacininfeathersofbroilerchickensbyhighperformanceliquidchromatographyfluorescenceafteroraladministrationofthedrugs
AT errecaldejorgeoscar quantificationofresidualenrofloxacinandciprofloxacininfeathersofbroilerchickensbyhighperformanceliquidchromatographyfluorescenceafteroraladministrationofthedrugs
bdutipo_str Repositorios
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