Pharmacokinetic and pharmacodynamic responses in adult patients with chagas disease treated with a new formulation of benznidazole

Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in children in all stages, but it is controversial in chronically infected adults. We report the pharmacokinetics and pharmacodynamics in six adult patients with Chagas disease treated with the new BNZ formulation (ABAR...

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Autores principales: Fernández, Marisa Liliana, Marson, María Elena, Ramírez, Juan Carlos, Mastrantonio Garrido, Guido Enrique, Schijman, Alejandro Gabriel, Altcheh, Jaime, Riarte, Adelina Rosa, García Bournissen, Facundo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Biología
Benznidazole
Chagas disease
Pharmacology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86271
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86271
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Benznidazole
Chagas disease
Pharmacology
spellingShingle Biología
Benznidazole
Chagas disease
Pharmacology
Fernández, Marisa Liliana
Marson, María Elena
Ramírez, Juan Carlos
Mastrantonio Garrido, Guido Enrique
Schijman, Alejandro Gabriel
Altcheh, Jaime
Riarte, Adelina Rosa
García Bournissen, Facundo
Pharmacokinetic and pharmacodynamic responses in adult patients with chagas disease treated with a new formulation of benznidazole
topic_facet Biología
Benznidazole
Chagas disease
Pharmacology
description Pharmacological treatment of Chagas disease with benznidazole (BNZ) is effective in children in all stages, but it is controversial in chronically infected adults. We report the pharmacokinetics and pharmacodynamics in six adult patients with Chagas disease treated with the new BNZ formulation (ABARAX®) in doses between 2.5-5.5 mg/Kg/ day. All but one patient had plasmatic BNZ concentrations within the expected range. All patients finalised treatment with nondetectable Trypanosoma cruzi quantitative polymerase chain reaction, which remained nondetectable at the six month follow-up. Our data suggests parasitological responses with the new BNZ and supports the hypothesis that treatment protocols with lower BNZ doses may be effective.
format Articulo
Articulo
author Fernández, Marisa Liliana
Marson, María Elena
Ramírez, Juan Carlos
Mastrantonio Garrido, Guido Enrique
Schijman, Alejandro Gabriel
Altcheh, Jaime
Riarte, Adelina Rosa
García Bournissen, Facundo
author_facet Fernández, Marisa Liliana
Marson, María Elena
Ramírez, Juan Carlos
Mastrantonio Garrido, Guido Enrique
Schijman, Alejandro Gabriel
Altcheh, Jaime
Riarte, Adelina Rosa
García Bournissen, Facundo
author_sort Fernández, Marisa Liliana
title Pharmacokinetic and pharmacodynamic responses in adult patients with chagas disease treated with a new formulation of benznidazole
title_short Pharmacokinetic and pharmacodynamic responses in adult patients with chagas disease treated with a new formulation of benznidazole
title_full Pharmacokinetic and pharmacodynamic responses in adult patients with chagas disease treated with a new formulation of benznidazole
title_fullStr Pharmacokinetic and pharmacodynamic responses in adult patients with chagas disease treated with a new formulation of benznidazole
title_full_unstemmed Pharmacokinetic and pharmacodynamic responses in adult patients with chagas disease treated with a new formulation of benznidazole
title_sort pharmacokinetic and pharmacodynamic responses in adult patients with chagas disease treated with a new formulation of benznidazole
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/86271
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