Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice

Metabolic functions are synchronized by the circadian clock setting daily patterns of food intake, nutrient delivery, and behavioral activity. Here, we study the impact of chronic jet-lag (CJL) on metabolism, and test manipulations aimed to overcome potential alterations. We recorded weight gain in...

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Detalles Bibliográficos
Autores principales: Casiraghi, Leandro P., Alzamendi, Ana, Giovambattista, Andrés, Chiesa, Juan J., Golombek, Diego Andrés
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Biología
Chronic jet-lag
Circadian disruption
Restricted feeding
Shift work
Wheel-running
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86255
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86255
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Chronic jet-lag
Circadian disruption
Restricted feeding
Shift work
Wheel-running
spellingShingle Biología
Chronic jet-lag
Circadian disruption
Restricted feeding
Shift work
Wheel-running
Casiraghi, Leandro P.
Alzamendi, Ana
Giovambattista, Andrés
Chiesa, Juan J.
Golombek, Diego Andrés
Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
topic_facet Biología
Chronic jet-lag
Circadian disruption
Restricted feeding
Shift work
Wheel-running
description Metabolic functions are synchronized by the circadian clock setting daily patterns of food intake, nutrient delivery, and behavioral activity. Here, we study the impact of chronic jet-lag (CJL) on metabolism, and test manipulations aimed to overcome potential alterations. We recorded weight gain in C57Bl/6 mice under chronic 6 h advances or delays of the light-dark cycle every 2 days (ChrA and ChrD, respectively). We have previously reported ChrA, but not ChrD, to induce forced desynchronization of locomotor activity rhythms in mice (Casiraghi et al. ). Body weight was rapidly increased under ChrA, with animals tripling the mean weight gain observed in controls by day 10, and doubling it by day 30 (6% vs. 2%, and 15% vs. 7%, respectively). Significant increases in retroperitoneal and epidydimal adipose tissue masses (172% and 61%, respectively), adipocytes size (28%), and circulating triglycerides (39%) were also detected. Daily patterns of food and water intake were abolished under ChrA. In contrast, ChrD had no effect on body weight. Wheel-running, housing of animals in groups, and restriction of food availability to hours of darkness prevented abnormal increase in body weight under ChrA. Our findings suggest that the observed alterations under ChrA may arise either from a direct effect of circadian disruption on metabolism, from desynchronization between feeding and metabolic rhythms, or both. Direction of shifts, timing of feeding episodes, and other reinforcing signals deeply affect the outcome of metabolic function under CJL. Such features should be taken into account in further studies of shift working schedules in humans.
format Articulo
Articulo
author Casiraghi, Leandro P.
Alzamendi, Ana
Giovambattista, Andrés
Chiesa, Juan J.
Golombek, Diego Andrés
author_facet Casiraghi, Leandro P.
Alzamendi, Ana
Giovambattista, Andrés
Chiesa, Juan J.
Golombek, Diego Andrés
author_sort Casiraghi, Leandro P.
title Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title_short Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title_full Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title_fullStr Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title_full_unstemmed Effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
title_sort effects of chronic forced circadian desynchronization on body weight and metabolism in male mice
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/86255
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