Human platelets and their capacity of binding viruses: meaning and challenges?

Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to the detection of danger signals, of which infect...

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Detalles Bibliográficos
Autores principales: Chabert, Adrien, Hamzeh Cognasse, Hind, Pozzetto, Bruno, Cognasse, Fabrice, Schattner, Mirta, Gómez, Ricardo Martín, Garraud, Oliver
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Exactas
Hemostasis
Infection
Platelets
Receptors
Viruses
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86127
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86127
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Hemostasis
Infection
Platelets
Receptors
Viruses
spellingShingle Ciencias Exactas
Hemostasis
Infection
Platelets
Receptors
Viruses
Chabert, Adrien
Hamzeh Cognasse, Hind
Pozzetto, Bruno
Cognasse, Fabrice
Schattner, Mirta
Gómez, Ricardo Martín
Garraud, Oliver
Human platelets and their capacity of binding viruses: meaning and challenges?
topic_facet Ciencias Exactas
Hemostasis
Infection
Platelets
Receptors
Viruses
description Blood platelets are first aimed at ensuring primary hemostasis. Beyond this role, they have been acknowledged as having functions in the maintenance of the vascular arborescence and, more recently, as being also innate immune cells, devoted notably to the detection of danger signals, of which infectious ones. Platelets express pathogen recognition receptors that can sense bacterial and viral moieties. Besides, several molecules that bind epithelial or sub-endothelial molecules and, so forth, are involved in hemostasis, happen to be able to ligate viral determinants, making platelets capable of either binding viruses or even to be infected by some of them. Further, as platelets express both Fc-receptors for Ig and complement receptors, they also bind occasionally virus-Ig or virus-Ig-complement immune complexes. Interplays of viruses with platelets are very complex and viral infections often interfere with platelet number and functions. Through a few instances of viral infections, the present review aims at presenting some of the most important interactions from pathophysiological and clinical points of view, which are observed between human viruses and platelets.
format Articulo
Revision
author Chabert, Adrien
Hamzeh Cognasse, Hind
Pozzetto, Bruno
Cognasse, Fabrice
Schattner, Mirta
Gómez, Ricardo Martín
Garraud, Oliver
author_facet Chabert, Adrien
Hamzeh Cognasse, Hind
Pozzetto, Bruno
Cognasse, Fabrice
Schattner, Mirta
Gómez, Ricardo Martín
Garraud, Oliver
author_sort Chabert, Adrien
title Human platelets and their capacity of binding viruses: meaning and challenges?
title_short Human platelets and their capacity of binding viruses: meaning and challenges?
title_full Human platelets and their capacity of binding viruses: meaning and challenges?
title_fullStr Human platelets and their capacity of binding viruses: meaning and challenges?
title_full_unstemmed Human platelets and their capacity of binding viruses: meaning and challenges?
title_sort human platelets and their capacity of binding viruses: meaning and challenges?
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/86127
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