Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"

The aim of this opinion article is to point out the basic principles that modify the assembly of biological membranes during lipid peroxidation. With this objective in mind, I describe: the structural and functional properties of membranes, the transport and diffusion of oxygen regulated by choleste...

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Autor principal: Catalá, Ángel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Exactas
Fluid mosaic model
Lipid peroxidation
Lipid whisker model
Membranes
PUFAs
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86114
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86114
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Fluid mosaic model
Lipid peroxidation
Lipid whisker model
Membranes
PUFAs
spellingShingle Ciencias Exactas
Fluid mosaic model
Lipid peroxidation
Lipid whisker model
Membranes
PUFAs
Catalá, Ángel
Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
topic_facet Ciencias Exactas
Fluid mosaic model
Lipid peroxidation
Lipid whisker model
Membranes
PUFAs
description The aim of this opinion article is to point out the basic principles that modify the assembly of biological membranes during lipid peroxidation. With this objective in mind, I describe: the structural and functional properties of membranes, the transport and diffusion of oxygen regulated by cholesterol and fatty acids; the "Lipid Whisker Model" and finally analyzed the changes induced by lipid peroxidation in membrane structure and dynamics, both at the lipid and protein level. Several reviews have appeared in recent years related to the kinetics and biology of lipid peroxidation products (Catala, 2010; Yin et al., 2011; Pinchuk and Lichtenberg, 2014; Vigor et al., 2014; Davies and Guo, 2014). The analysis of lipid peroxidation products has been particularly important in the advancement of research in this field because of the complexity of product mixtures. I also discuss the effect of other membrane modifications, triggered by lipid peroxidation products and reducing sugars. Contrary to what is expected by the LWM, Garrec et al. (2014) have recently investigated the validity of the "floating peroxyl radical" hypothesis by means of molecular modeling and predicted that the peroxyl radical does not "float" at the surface of the membrane.
format Articulo
Articulo
author Catalá, Ángel
author_facet Catalá, Ángel
author_sort Catalá, Ángel
title Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title_short Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title_full Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title_fullStr Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title_full_unstemmed Lipid peroxidation modifies the assembly of biological membranes "The Lipid Whisker Model"
title_sort lipid peroxidation modifies the assembly of biological membranes "the lipid whisker model"
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/86114
work_keys_str_mv AT catalaangel lipidperoxidationmodifiestheassemblyofbiologicalmembranesthelipidwhiskermodel
bdutipo_str Repositorios
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