Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms

Several single nucleotide polymorphisms (SNPs) in the Mu Opioid Receptor gene (OPRM1) have been identified and associated with a wide variety of clinical phenotypes related both to pain sensitivity and analgesic requirements. The A118G and other potentially functional OPRM1 SNPs show significant dif...

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Detalles Bibliográficos
Autores principales: López Soto, Eduardo Javier, Catanesi, Cecilia Inés
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Naturales
A118G
AMOVA
OPRM1
Population genetics
SNPs
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86108
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86108
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
A118G
AMOVA
OPRM1
Population genetics
SNPs
spellingShingle Ciencias Naturales
A118G
AMOVA
OPRM1
Population genetics
SNPs
López Soto, Eduardo Javier
Catanesi, Cecilia Inés
Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms
topic_facet Ciencias Naturales
A118G
AMOVA
OPRM1
Population genetics
SNPs
description Several single nucleotide polymorphisms (SNPs) in the Mu Opioid Receptor gene (OPRM1) have been identified and associated with a wide variety of clinical phenotypes related both to pain sensitivity and analgesic requirements. The A118G and other potentially functional OPRM1 SNPs show significant differences in their allele distributions among populations. However, they have not been properly addressed in a population genetic analysis. Population stratification could lead to erroneous conclusions when they are not taken into account in association studies. The aim of our study was to analyze OPRM1 SNP variability by comparing population samples of the International Hap Map database and to analyze a new population sample from the city of Corrientes, Argentina. The results confirm that OPRM1 SNP variability differs among human populations and displays a clear ancestry genetic structure, with three population clusters: Africa, Asia, and Europe-America.
format Articulo
Comunicacion
author López Soto, Eduardo Javier
Catanesi, Cecilia Inés
author_facet López Soto, Eduardo Javier
Catanesi, Cecilia Inés
author_sort López Soto, Eduardo Javier
title Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms
title_short Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms
title_full Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms
title_fullStr Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms
title_full_unstemmed Human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms
title_sort human population genetic structure detected by pain-related mu opioid receptor gene polymorphisms
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/86108
work_keys_str_mv AT lopezsotoeduardojavier humanpopulationgeneticstructuredetectedbypainrelatedmuopioidreceptorgenepolymorphisms
AT catanesiceciliaines humanpopulationgeneticstructuredetectedbypainrelatedmuopioidreceptorgenepolymorphisms
bdutipo_str Repositorios
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