Systems biology approach to model the life cycle of Trypanosoma cruzi

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Due to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we pr...

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Autores principales: Carrea, Alejandra, Diambra, Luis Aníbal
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Biología
Trypanosoma cruzi
Parasites
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86040
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86040
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Trypanosoma cruzi
Parasites
spellingShingle Biología
Trypanosoma cruzi
Parasites
Carrea, Alejandra
Diambra, Luis Aníbal
Systems biology approach to model the life cycle of Trypanosoma cruzi
topic_facet Biología
Trypanosoma cruzi
Parasites
description Due to recent advances in reprogramming cell phenotypes, many efforts have been dedicated to developing reverse engineering procedures for the identification of gene regulatory networks that emulate dynamical properties associated with the cell fates of a given biological system. In this work, we propose a systems biology approach for the reconstruction of the gene regulatory network underlying the dynamics of the Trypanosoma cruzi's life cycle. By means of an optimisation procedure, we embedded the steady state maintenance, and the known phenotypic transitions between these steady states in response to environmental cues, into the dynamics of a gene network model. In the resulting network architecture we identified a small subnetwork, formed by seven interconnected nodes, that controls the parasite's life cycle. The present approach could be useful for better understanding other single cell organisms with multiple developmental stages.
format Articulo
Articulo
author Carrea, Alejandra
Diambra, Luis Aníbal
author_facet Carrea, Alejandra
Diambra, Luis Aníbal
author_sort Carrea, Alejandra
title Systems biology approach to model the life cycle of Trypanosoma cruzi
title_short Systems biology approach to model the life cycle of Trypanosoma cruzi
title_full Systems biology approach to model the life cycle of Trypanosoma cruzi
title_fullStr Systems biology approach to model the life cycle of Trypanosoma cruzi
title_full_unstemmed Systems biology approach to model the life cycle of Trypanosoma cruzi
title_sort systems biology approach to model the life cycle of trypanosoma cruzi
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/86040
work_keys_str_mv AT carreaalejandra systemsbiologyapproachtomodelthelifecycleoftrypanosomacruzi
AT diambraluisanibal systemsbiologyapproachtomodelthelifecycleoftrypanosomacruzi
bdutipo_str Repositorios
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