First report of cerebellar abiotrophy in an Arabian foal from Argentina

Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious ence...

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Autores principales: Sadaba, Sebastián Andres, Madariaga, G.J, Corbi Botto, Claudia, Carino, Mónica H., Zappa, María Eugenia, Peral García, Pilar, Olguín, Silvia Andrea, Massone, Adriana Raquel, Díaz, Silvina
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Veterinarias
Apoptosis
Arabian horses
Cerebellar abiotrophy
DNA
Purkinje cells
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85963
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85963
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Apoptosis
Arabian horses
Cerebellar abiotrophy
DNA
Purkinje cells
spellingShingle Ciencias Veterinarias
Apoptosis
Arabian horses
Cerebellar abiotrophy
DNA
Purkinje cells
Sadaba, Sebastián Andres
Madariaga, G.J
Corbi Botto, Claudia
Carino, Mónica H.
Zappa, María Eugenia
Peral García, Pilar
Olguín, Silvia Andrea
Massone, Adriana Raquel
Díaz, Silvina
First report of cerebellar abiotrophy in an Arabian foal from Argentina
topic_facet Ciencias Veterinarias
Apoptosis
Arabian horses
Cerebellar abiotrophy
DNA
Purkinje cells
description Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.
format Articulo
Articulo
author Sadaba, Sebastián Andres
Madariaga, G.J
Corbi Botto, Claudia
Carino, Mónica H.
Zappa, María Eugenia
Peral García, Pilar
Olguín, Silvia Andrea
Massone, Adriana Raquel
Díaz, Silvina
author_facet Sadaba, Sebastián Andres
Madariaga, G.J
Corbi Botto, Claudia
Carino, Mónica H.
Zappa, María Eugenia
Peral García, Pilar
Olguín, Silvia Andrea
Massone, Adriana Raquel
Díaz, Silvina
author_sort Sadaba, Sebastián Andres
title First report of cerebellar abiotrophy in an Arabian foal from Argentina
title_short First report of cerebellar abiotrophy in an Arabian foal from Argentina
title_full First report of cerebellar abiotrophy in an Arabian foal from Argentina
title_fullStr First report of cerebellar abiotrophy in an Arabian foal from Argentina
title_full_unstemmed First report of cerebellar abiotrophy in an Arabian foal from Argentina
title_sort first report of cerebellar abiotrophy in an arabian foal from argentina
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/85963
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