Cigarette smoking, dietary habits and genetic polymorphisms in <i>GSTT1</i>, <i>GSTM1</i> and <i>CYP1A1</i> metabolic genes: A case-control study in oncohematological diseases

Aim: To analyze the association between oncohematological diseases and <i>GSTT1 /GSTM1 /CYP1A1</i> polymorphisms, dietary habits and smoking, in an argentine hospitalbased case-control study. Methods: This hospital-based case-control study involved 125 patients with oncohematological di...

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Autores principales: Cerliani, María Belén, Pavicic, Walter Hernán, Gili, Juan Antonio, Klein, Graciela, Saba, Silvia, Richard, Silvina Mariel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Exactas
Ciencias Médicas
Cancer
Casecontrol study
CYP1A1
Diet
GSTM1
GSTT1
Lifestyle
Oncohematological disease
Tobacco
Xenobiotic metabolizing genes
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85925
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85925
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Ciencias Médicas
Cancer
Casecontrol study
CYP1A1
Diet
GSTM1
GSTT1
Lifestyle
Oncohematological disease
Tobacco
Xenobiotic metabolizing genes
spellingShingle Ciencias Exactas
Ciencias Médicas
Cancer
Casecontrol study
CYP1A1
Diet
GSTM1
GSTT1
Lifestyle
Oncohematological disease
Tobacco
Xenobiotic metabolizing genes
Cerliani, María Belén
Pavicic, Walter Hernán
Gili, Juan Antonio
Klein, Graciela
Saba, Silvia
Richard, Silvina Mariel
Cigarette smoking, dietary habits and genetic polymorphisms in <i>GSTT1</i>, <i>GSTM1</i> and <i>CYP1A1</i> metabolic genes: A case-control study in oncohematological diseases
topic_facet Ciencias Exactas
Ciencias Médicas
Cancer
Casecontrol study
CYP1A1
Diet
GSTM1
GSTT1
Lifestyle
Oncohematological disease
Tobacco
Xenobiotic metabolizing genes
description Aim: To analyze the association between oncohematological diseases and <i>GSTT1 /GSTM1 /CYP1A1</i> polymorphisms, dietary habits and smoking, in an argentine hospitalbased case-control study. Methods: This hospital-based case-control study involved 125 patients with oncohematological diseases and 310 control subjects. A questionnaire was used to obtain sociodemographic data and information about habits. Blood samples were collected, and DNA was extracted using salting out methods. Deletions in <i>GSTT1</i> and <i>GSTM1</i> (null genotypes) were addressed by PCR. <i>CYP1A1 MspI</i> polymorphism was detected by PCR-RFLP. Odds ratio (OR) and 95%CI were calculated to estimate the association between each variable studied and oncohematological disease. Results: Women showed lower risk of disease compared to men (OR 0.52, 95%CI: 0.34-0.82, P = 0.003). Higher levels of education (> 12 years) were significantly associated with an increased risk, compared to complete primary school or less (OR 3.68, 95%CI: 1.82-7.40, P < 0.001 adjusted for age and sex). With respect to tobacco, none of the smoking categories showed association with oncohematological diseases. Regarding dietary habits, consumption of grilled/barbecued meat 3 or more times per month showed significant association with an increased risk of disease (OR 1.72, 95%CI: 1.08-2.75, P = 0.02). Daily consumption of coffee also was associated with an increased risk (OR 1.77, 95%CI: 1.03-3.03, P = 0.03). Results for <i>GSTT1</i>, <i>GSTM1</i> and <i>CYP1A1</i> polymorphisms showed no significant association with oncohematological diseases. When analyzing the interaction between polymorphisms and tobacco smoking or dietary habits, no statistically significant associations that modify disease risk were found. Conclusion: We reported an increased risk of oncohematological diseases associated with meat and coffee intake. We did not find significant associations between genetic polymorphisms and blood cancer.
format Articulo
Articulo
author Cerliani, María Belén
Pavicic, Walter Hernán
Gili, Juan Antonio
Klein, Graciela
Saba, Silvia
Richard, Silvina Mariel
author_facet Cerliani, María Belén
Pavicic, Walter Hernán
Gili, Juan Antonio
Klein, Graciela
Saba, Silvia
Richard, Silvina Mariel
author_sort Cerliani, María Belén
title Cigarette smoking, dietary habits and genetic polymorphisms in <i>GSTT1</i>, <i>GSTM1</i> and <i>CYP1A1</i> metabolic genes: A case-control study in oncohematological diseases
title_short Cigarette smoking, dietary habits and genetic polymorphisms in <i>GSTT1</i>, <i>GSTM1</i> and <i>CYP1A1</i> metabolic genes: A case-control study in oncohematological diseases
title_full Cigarette smoking, dietary habits and genetic polymorphisms in <i>GSTT1</i>, <i>GSTM1</i> and <i>CYP1A1</i> metabolic genes: A case-control study in oncohematological diseases
title_fullStr Cigarette smoking, dietary habits and genetic polymorphisms in <i>GSTT1</i>, <i>GSTM1</i> and <i>CYP1A1</i> metabolic genes: A case-control study in oncohematological diseases
title_full_unstemmed Cigarette smoking, dietary habits and genetic polymorphisms in <i>GSTT1</i>, <i>GSTM1</i> and <i>CYP1A1</i> metabolic genes: A case-control study in oncohematological diseases
title_sort cigarette smoking, dietary habits and genetic polymorphisms in <i>gstt1</i>, <i>gstm1</i> and <i>cyp1a1</i> metabolic genes: a case-control study in oncohematological diseases
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/85925
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