Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice
Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One of the most frequent and potentially life threatening disorders of DM-induced heart disease is ventricular tachycardia (VT). Here we show that toll-like receptor 2 (TLR2) and NLRP3 inflammasome activa...
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2016
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/85910 |
| Aporte de: |
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I19-R120-10915-85910 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Ciencias Exactas Diabetes Mellitus IL-1β |
| spellingShingle |
Ciencias Médicas Ciencias Exactas Diabetes Mellitus IL-1β Monnerat, Gustavo Alarcón, Micaela L. Vasconcellos, Luiz R. Hochman Mendez, Camila Brasil, Guilherme Bassani, Rosana A. Casis, Oscar Malan, Daniela Travassos, Leonardo H. Sepúlveda, Marisa Noemí Burgos, Juan Ignacio Vila Petroff, Martín Gerardo Dutra, Fabiano F. Bozza, Marcelo T. Paiva, Claudia N. Bustos Carvalho, Adriana Bonomo, Adriana Fleischmann, Bernd K. Campos de Carvalho, Antonio Carlos Medei, Emiliano Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| topic_facet |
Ciencias Médicas Ciencias Exactas Diabetes Mellitus IL-1β |
| description |
Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One of the most frequent and potentially life threatening disorders of DM-induced heart disease is ventricular tachycardia (VT). Here we show that toll-like receptor 2 (TLR2) and NLRP3 inflammasome activation in cardiac macrophages mediate the production of IL-1β in DM mice. IL-1β causes prolongation of the action potential duration, induces a decrease in potassium current and an increase in calcium sparks in cardiomyocytes, which are changes that underlie arrhythmia propensity. IL-1β-induced spontaneous contractile events are associated with CaMKII oxidation and phosphorylation. We further show that DM-induced arrhythmias can be successfully treated by inhibiting the IL-1β axis with either IL-1 receptor antagonist or by inhibiting the NLRP3 inflammasome. Our results establish IL-1β as an inflammatory connection between metabolic dysfunction and arrhythmias in DM. |
| format |
Articulo Articulo |
| author |
Monnerat, Gustavo Alarcón, Micaela L. Vasconcellos, Luiz R. Hochman Mendez, Camila Brasil, Guilherme Bassani, Rosana A. Casis, Oscar Malan, Daniela Travassos, Leonardo H. Sepúlveda, Marisa Noemí Burgos, Juan Ignacio Vila Petroff, Martín Gerardo Dutra, Fabiano F. Bozza, Marcelo T. Paiva, Claudia N. Bustos Carvalho, Adriana Bonomo, Adriana Fleischmann, Bernd K. Campos de Carvalho, Antonio Carlos Medei, Emiliano |
| author_facet |
Monnerat, Gustavo Alarcón, Micaela L. Vasconcellos, Luiz R. Hochman Mendez, Camila Brasil, Guilherme Bassani, Rosana A. Casis, Oscar Malan, Daniela Travassos, Leonardo H. Sepúlveda, Marisa Noemí Burgos, Juan Ignacio Vila Petroff, Martín Gerardo Dutra, Fabiano F. Bozza, Marcelo T. Paiva, Claudia N. Bustos Carvalho, Adriana Bonomo, Adriana Fleischmann, Bernd K. Campos de Carvalho, Antonio Carlos Medei, Emiliano |
| author_sort |
Monnerat, Gustavo |
| title |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_short |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_full |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_fullStr |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_full_unstemmed |
Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice |
| title_sort |
macrophage-dependent il-1β production induces cardiac arrhythmias in diabetic mice |
| publishDate |
2016 |
| url |
http://sedici.unlp.edu.ar/handle/10915/85910 |
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