Influence of Vectors' Risk-Spreading Strategies and Environmental Stochasticity on the Epidemiology and Evolution of Vector-Borne Diseases: The Example of Chagas' Disease

Insects are known to display strategies that spread the risk of encountering unfavorable conditions, thereby decreasing the extinction probability of genetic lineages in unpredictable environments. To what extent these strategies influence the epidemiology and evolution of vector-borne diseases in s...

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Detalles Bibliográficos
Autores principales: Pelosse, Perrine, Kribs-Zaleta, Christopher M., Ginoux, Marine, Rabinovich, Jorge E., Gourbière, Sébastien, Menu, Frédéric
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Biología
Triatoma
Chagas Disease
Triatomine species
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85508
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85508
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Triatoma
Chagas Disease
Triatomine species
spellingShingle Biología
Triatoma
Chagas Disease
Triatomine species
Pelosse, Perrine
Kribs-Zaleta, Christopher M.
Ginoux, Marine
Rabinovich, Jorge E.
Gourbière, Sébastien
Menu, Frédéric
Influence of Vectors' Risk-Spreading Strategies and Environmental Stochasticity on the Epidemiology and Evolution of Vector-Borne Diseases: The Example of Chagas' Disease
topic_facet Biología
Triatoma
Chagas Disease
Triatomine species
description Insects are known to display strategies that spread the risk of encountering unfavorable conditions, thereby decreasing the extinction probability of genetic lineages in unpredictable environments. To what extent these strategies influence the epidemiology and evolution of vector-borne diseases in stochastic environments is largely unknown. In triatomines, the vectors of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease, juvenile development time varies between individuals and such variation most likely decreases the extinction risk of vector populations in stochastic environments. We developed a simplified multi-stage vector-borne SI epidemiological model to investigate how vector risk-spreading strategies and environmental stochasticity influence the prevalence and evolution of a parasite. This model is based on available knowledge on triatomine biodemography, but its conceptual outcomes apply, to a certain extent, to other vector-borne diseases. Model comparisons between deterministic and stochastic settings led to the conclusion that environmental stochasticity, vector risk-spreading strategies (in particular an increase in the length and variability of development time) and their interaction have drastic consequences on vector population dynamics, disease prevalence, and the relative short-term evolution of parasite virulence. Our work shows that stochastic environments and associated risk-spreading strategies can increase the prevalence of vector-borne diseases and favor the invasion of more virulent parasite strains on relatively short evolutionary timescales. This study raises new questions and challenges in a context of increasingly unpredictable environmental variations as a result of global climate change and human interventions such as habitat destruction or vector control.
format Articulo
Articulo
author Pelosse, Perrine
Kribs-Zaleta, Christopher M.
Ginoux, Marine
Rabinovich, Jorge E.
Gourbière, Sébastien
Menu, Frédéric
author_facet Pelosse, Perrine
Kribs-Zaleta, Christopher M.
Ginoux, Marine
Rabinovich, Jorge E.
Gourbière, Sébastien
Menu, Frédéric
author_sort Pelosse, Perrine
title Influence of Vectors' Risk-Spreading Strategies and Environmental Stochasticity on the Epidemiology and Evolution of Vector-Borne Diseases: The Example of Chagas' Disease
title_short Influence of Vectors' Risk-Spreading Strategies and Environmental Stochasticity on the Epidemiology and Evolution of Vector-Borne Diseases: The Example of Chagas' Disease
title_full Influence of Vectors' Risk-Spreading Strategies and Environmental Stochasticity on the Epidemiology and Evolution of Vector-Borne Diseases: The Example of Chagas' Disease
title_fullStr Influence of Vectors' Risk-Spreading Strategies and Environmental Stochasticity on the Epidemiology and Evolution of Vector-Borne Diseases: The Example of Chagas' Disease
title_full_unstemmed Influence of Vectors' Risk-Spreading Strategies and Environmental Stochasticity on the Epidemiology and Evolution of Vector-Borne Diseases: The Example of Chagas' Disease
title_sort influence of vectors' risk-spreading strategies and environmental stochasticity on the epidemiology and evolution of vector-borne diseases: the example of chagas' disease
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/85508
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