Mitochondrial NHE1: a newly identified target to prevent heart disease

Mitochondrial damage has been associated with early steps of cardiac dysfunction in heart subjected to ischemic stress, oxidative stress and hypertrophy. A common feature for the mitochondrial deterioration is the loss of the mitochondrial membrane potential (δψm) with the concomitant irreversible o...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Álvarez, Bernardo Víctor, Villa Abrille, María Celeste
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Médicas
Ischemia
Mitochondrial permeability transition pore
Mitochondrial swelling
NHE1
Sirna
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85471
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85471
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Ischemia
Mitochondrial permeability transition pore
Mitochondrial swelling
NHE1
Sirna
spellingShingle Ciencias Médicas
Ischemia
Mitochondrial permeability transition pore
Mitochondrial swelling
NHE1
Sirna
Álvarez, Bernardo Víctor
Villa Abrille, María Celeste
Mitochondrial NHE1: a newly identified target to prevent heart disease
topic_facet Ciencias Médicas
Ischemia
Mitochondrial permeability transition pore
Mitochondrial swelling
NHE1
Sirna
description Mitochondrial damage has been associated with early steps of cardiac dysfunction in heart subjected to ischemic stress, oxidative stress and hypertrophy. A common feature for the mitochondrial deterioration is the loss of the mitochondrial membrane potential (δψm) with the concomitant irreversible opening of the mitochondrial permeability transition pore (MPTP) which follows the mitochondrial Ca<SUP>2+</SUP> overload, and the subsequent mitochondrial swelling. We have recently characterized the expression of the Na<SUP>+</SUP>/H<SUP>+</SUP> exchanger 1 (mNHE1) in mitochondrial membranes. This surprising observation provided a unique target for the prevention of the Ca<SUP>2+</SUP>-induced MPTP opening, based on the inhibition of the NHE1 m. In this line, inhibition of NHE1 m activity and/or reduction of NHE1 m expression decreased the Ca<SUP>2+</SUP>-induced mitochondrial swelling and the release of reactive oxygen species (ROS) in isolated cardiac mitochondria and preserved the δψm in isolated cardiomyocytes. Mitochondrial NHE1 thus represents a novel target to prevent cardiac disease, opening new avenues for future research.
format Articulo
Revision
author Álvarez, Bernardo Víctor
Villa Abrille, María Celeste
author_facet Álvarez, Bernardo Víctor
Villa Abrille, María Celeste
author_sort Álvarez, Bernardo Víctor
title Mitochondrial NHE1: a newly identified target to prevent heart disease
title_short Mitochondrial NHE1: a newly identified target to prevent heart disease
title_full Mitochondrial NHE1: a newly identified target to prevent heart disease
title_fullStr Mitochondrial NHE1: a newly identified target to prevent heart disease
title_full_unstemmed Mitochondrial NHE1: a newly identified target to prevent heart disease
title_sort mitochondrial nhe1: a newly identified target to prevent heart disease
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/85471
work_keys_str_mv AT alvarezbernardovictor mitochondrialnhe1anewlyidentifiedtargettopreventheartdisease
AT villaabrillemariaceleste mitochondrialnhe1anewlyidentifiedtargettopreventheartdisease
bdutipo_str Repositorios
_version_ 1764820489430106116

Ejemplares similares