Gsk-3 β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats

The aim of this study was to examine the effects of GSK-3β inhibitors compared with PRE and POS in spontaneously hypertensive rats (SHR). Isolated hearts were submitted to the following protocols: IC: 45 min global ischemia (GI) and 1-hour reperfusion (R); PRE: a cycle of 5 min GI and 10 minutes of...

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Autores principales: González Arbeláez, Luisa Fernanda, Peréz Núñez, Ignacio Adrián, Mosca, Susana María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Médicas
Infarct
Oxidative stress
GSK-3β
Inhibitors
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85466
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85466
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Infarct
Oxidative stress
GSK-3β
Inhibitors
spellingShingle Ciencias Médicas
Infarct
Oxidative stress
GSK-3β
Inhibitors
González Arbeláez, Luisa Fernanda
Peréz Núñez, Ignacio Adrián
Mosca, Susana María
Gsk-3 β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats
topic_facet Ciencias Médicas
Infarct
Oxidative stress
GSK-3β
Inhibitors
description The aim of this study was to examine the effects of GSK-3β inhibitors compared with PRE and POS in spontaneously hypertensive rats (SHR). Isolated hearts were submitted to the following protocols: IC: 45 min global ischemia (GI) and 1-hour reperfusion (R); PRE: a cycle of 5 min GI and 10 minutes of R prior to 45 min GI; POS: three cycles of 30 sec GI/30 sec R at the start of R. Other hearts received lithium chloride (LiCl) or indirubin-3′-monoxime,5- iodo-(IMI) as GSK-3β inhibitors. All interventions reduced the infarct size observed in IC group. The expressions of P-GSK-3β and P-Akt decreased in IC and were restored after PRE, POS, and GSK-3β inhibitors treatments. An increase of cytosolic MnSOD activity and lipid peroxidation and a decrease of GSH content observed in IC hearts were attenuated in PRE, POS, and LiCl or IMI treatments. An increase of P-GSK-3β/VDAC physical association and a partial recovery of mitochondrial permeability were also detected after interventions. These data show that, in SHR hearts, GSK-3β inhibitors mimic the cardioprotection afforded by PRE and POS and suggest that a decrease in mitochondrial permeability mediated by P-GSK-3β/VDAC interaction is a crucial event.
format Articulo
Articulo
author González Arbeláez, Luisa Fernanda
Peréz Núñez, Ignacio Adrián
Mosca, Susana María
author_facet González Arbeláez, Luisa Fernanda
Peréz Núñez, Ignacio Adrián
Mosca, Susana María
author_sort González Arbeláez, Luisa Fernanda
title Gsk-3 β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats
title_short Gsk-3 β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats
title_full Gsk-3 β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats
title_fullStr Gsk-3 β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats
title_full_unstemmed Gsk-3 β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats
title_sort gsk-3 β inhibitors mimic the cardioprotection mediated by ischemic pre- and postconditioning in hypertensive rats
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/85466
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bdutipo_str Repositorios
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