Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers

Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorl...

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Detalles Bibliográficos
Autores principales: Schattner, Mirta, Rivadeneyra, Leonardo, Pozner, Roberto G., Gómez, Ricardo Martín
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2013
Materias:
Biología
Coagulation
Endothelium
Hemostasis
Interferon
Megakaryocytes
Nitric oxide
Platelets
Thrombocytopenia
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85432
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85432
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Coagulation
Endothelium
Hemostasis
Interferon
Megakaryocytes
Nitric oxide
Platelets
Thrombocytopenia
spellingShingle Biología
Coagulation
Endothelium
Hemostasis
Interferon
Megakaryocytes
Nitric oxide
Platelets
Thrombocytopenia
Schattner, Mirta
Rivadeneyra, Leonardo
Pozner, Roberto G.
Gómez, Ricardo Martín
Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
topic_facet Biología
Coagulation
Endothelium
Hemostasis
Interferon
Megakaryocytes
Nitric oxide
Platelets
Thrombocytopenia
description Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.
format Articulo
Revision
author Schattner, Mirta
Rivadeneyra, Leonardo
Pozner, Roberto G.
Gómez, Ricardo Martín
author_facet Schattner, Mirta
Rivadeneyra, Leonardo
Pozner, Roberto G.
Gómez, Ricardo Martín
author_sort Schattner, Mirta
title Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title_short Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title_full Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title_fullStr Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title_full_unstemmed Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
title_sort pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/85432
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