Noise minimisation in gene expression switches

Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations...

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Autores principales: Monteoliva, Diana, McCarthy, Christina Beryl, Diambra, Luis Aníbal
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Exactas
Gene expression
Noise minimisation
cis-regulatory system
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85357
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85357
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Gene expression
Noise minimisation
cis-regulatory system
spellingShingle Ciencias Exactas
Gene expression
Noise minimisation
cis-regulatory system
Monteoliva, Diana
McCarthy, Christina Beryl
Diambra, Luis Aníbal
Noise minimisation in gene expression switches
topic_facet Ciencias Exactas
Gene expression
Noise minimisation
cis-regulatory system
description Gene expression is subject to stochastic variation which leads to fluctuations in the rate of protein production. Recently, a study in yeast at a genomic scale showed that, in some cases, gene expression variability alters phenotypes while, in other cases, these remain unchanged despite fluctuations in the expression of other genes. These studies suggested that noise in gene expression is a physiologically relevant trait and, to prevent harmful stochastic variation in the expression levels of some genes, it can be subject to minimisation. However, the mechanisms for noise minimisation are still unclear. In the present work, we analysed how noise expression depends on the architecture of the <i>cis</i>-regulatory system, in particular on the number of regulatory binding sites. Using analytical calculations and stochastic simulations, we found that the fluctuation level in noise expression decreased with the number of regulatory sites when regulatory transcription factors interacted with only one other bound transcription factor. In contrast, we observed that there was an optimal number of binding sites when transcription factors interacted with many bound transcription factors. This finding suggested a new mechanism for preventing large fluctuations in the expression of genes which are sensitive to the concentration of regulators.
format Articulo
Articulo
author Monteoliva, Diana
McCarthy, Christina Beryl
Diambra, Luis Aníbal
author_facet Monteoliva, Diana
McCarthy, Christina Beryl
Diambra, Luis Aníbal
author_sort Monteoliva, Diana
title Noise minimisation in gene expression switches
title_short Noise minimisation in gene expression switches
title_full Noise minimisation in gene expression switches
title_fullStr Noise minimisation in gene expression switches
title_full_unstemmed Noise minimisation in gene expression switches
title_sort noise minimisation in gene expression switches
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/85357
work_keys_str_mv AT monteolivadiana noiseminimisationingeneexpressionswitches
AT mccarthychristinaberyl noiseminimisationingeneexpressionswitches
AT diambraluisanibal noiseminimisationingeneexpressionswitches
bdutipo_str Repositorios
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