Gender differences in cardiac left ventricular mass and function: clinical and experimental observations

Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats. LVM and LVF were evaluated in animals and hum...

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Autores principales: Escudero, Eduardo Manuel, Orlowski, Alejandro, Díaz, Alberto Alejandro, Pinilla, Oscar Andrés, Ennis, Irene Lucía, Aiello, Ernesto Alejandro
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Ciencias Médicas
Cardiac function
Cardiac hypertrophy
Cardiac myocytes
Sex differences
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/85323
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-85323
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Cardiac function
Cardiac hypertrophy
Cardiac myocytes
Sex differences
spellingShingle Ciencias Médicas
Cardiac function
Cardiac hypertrophy
Cardiac myocytes
Sex differences
Escudero, Eduardo Manuel
Orlowski, Alejandro
Díaz, Alberto Alejandro
Pinilla, Oscar Andrés
Ennis, Irene Lucía
Aiello, Ernesto Alejandro
Gender differences in cardiac left ventricular mass and function: clinical and experimental observations
topic_facet Ciencias Médicas
Cardiac function
Cardiac hypertrophy
Cardiac myocytes
Sex differences
description Background: The aim of this study was to evaluate gender-associated impact on left ventricular mass (LVM) and on left ventricular function (LVF) in humans and rats with aging. Methods: Myocyte area and collagen volume fraction (CVF) were studied in rats. LVM and LVF were evaluated in animals and humans by echocardiography and LVM index (LVMI) was obtained. Results: LVMI, myocyte area and CVF were similar in males and females of 1-month-old rats. LVMI in children was similar in both genders. In contrast, in 6-month-old rats (5 males and 5 females), LVMI (17.7 ± 0.7 mg/mm vs. 10.1 ± 0.2 mg/mm; p < 0.01), and myocyte area (4572.5 ± 72.6 μm2 vs. 3293.85 ± 57.8 μm2, p < 0.01) were higher in male animals without differences in CVF. Men (n = 25) exhibited greater LVMI than women (n = 25) (77.4 ± 3.2 g/m2 vs. 63.3 ± 1.8 g/m2, p < 0.01), whereas the LVF was higher in women (105.9 ± 2.9% vs. 95.3 ± 3.5%, p < 0.01). Conclusions: There is a clear gender-associated impact on LVM with aging in humans and rats. Similar CVF and LVF associated to greater myocyte size and LVM in male rats suggest a process of physiological response. However, the increase in cardiac mass without an associated improved cardiac function in men in comparison to women could likely represent a potential disadvantage in the adaptive response during growth.
format Articulo
Articulo
author Escudero, Eduardo Manuel
Orlowski, Alejandro
Díaz, Alberto Alejandro
Pinilla, Oscar Andrés
Ennis, Irene Lucía
Aiello, Ernesto Alejandro
author_facet Escudero, Eduardo Manuel
Orlowski, Alejandro
Díaz, Alberto Alejandro
Pinilla, Oscar Andrés
Ennis, Irene Lucía
Aiello, Ernesto Alejandro
author_sort Escudero, Eduardo Manuel
title Gender differences in cardiac left ventricular mass and function: clinical and experimental observations
title_short Gender differences in cardiac left ventricular mass and function: clinical and experimental observations
title_full Gender differences in cardiac left ventricular mass and function: clinical and experimental observations
title_fullStr Gender differences in cardiac left ventricular mass and function: clinical and experimental observations
title_full_unstemmed Gender differences in cardiac left ventricular mass and function: clinical and experimental observations
title_sort gender differences in cardiac left ventricular mass and function: clinical and experimental observations
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/85323
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